Cell-Based Biosensors and Bio-MEMS for Its New Applications  

作　　者：Ping Wang 

机构地区：[1]Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China

出　　处：《稀有金属材料与工程》2006年第A03期47-50,共4页Rare Metal Materials and Engineering

基　　金：Acknowledgement： This work was supported by the National Natural Science Foundation of China （Grant Nos. 30270387, No. 30570492）；the Project of State Key Laboratory of Transducer Technology of China （Grant No. SKT0403）；the Foundation for the Bureau of Zhejiang Province of China （Grant No. 20040197）.

摘　　要：This paper reviews a novel cell-based biosensor and Bio-MEMS which incorporate living cells as sensing elements that convert a change in immediate environment to signals conducive for processing.It is characterized with high sensitivity,excellent selectivity and fast response and have been implemented for a number of applications ranging from pharmaceutical screening to environmental pollutant detection.This paper also introduces our recent work about Light-Addressable Potentiometric Sensors (LAPS),Field Effect Transistor (FET),Micro-Electrode Array Sensors (MEAS) and Bio-MEMS for detecting the changes of concentration of extracellular ions and the action potential of living cell under effect of drugs and environmental parameters.Finely, the paper gives some prospects of cell-based biosensors in the future.This paper reviews a novel cell-based biosensor and Bio-MEMS which incorporate living cells as sensing elements that convert a change in immediate environment to signals conducive for processing. It is characterized with high sensitivity, excellent selectivity and fast response and have been implemented for a number of applications ranging from pharmaceutical screening to environmental pollutant detection. This paper also introduces our recent work about Light-Addressable Potentiometric Sensors （LAPS）, Field Effect Transistor（FET）, Micro-Electrode Array Sensors（MEAS） and Bio-MEMS for detecting the changes of concentration of extracellular ions and the action potential of living cell under effect of drugs and environmental parameters. Finely, the paper gives some prospects of cell-based biosensors in the future.

关 键 词：cell-based sensors BIO-MEMS biosensors LAPS FET MEAS 

分 类 号：TG[金属学及工艺]