Neurochip Based on Light-addressable Potentiometric Sensor  

作　　者：Qingjun Liu Hua Cai Ying Xu Lifeng Qin Lijiang Wang Ping Wang 

机构地区：[1]Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China [2]State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai 200050, China

出　　处：《稀有金属材料与工程》2006年第A03期413-416,共4页Rare Metal Materials and Engineering

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.30270387,No.30570492);the Project of State Key Laboratory of Transducer Technology of China(Grant No.SKT0403);the Foundation for the Bureau of Zhejiang Province of China(Grant No.20040197).

摘　　要：<正>A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed.Using its light addressable characteristic.The problems of the limitations of restricted discrete active sites of current neurochips,such as microelectrode array and field effect transistor array can be settled easily.Based on the theoretical analysis of the interface between cells and LAPS,spontaneously discharges of hippocampal neurons induced by Mg~ 2+)-free media treatment were recorded by LAPS.The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.A novel neurochip based on light addressable potentiometric sensor （LAPS） is designed. Using its light addressable characteristic. The problems of the limitations of restricted discrete active sites of current neurochips, such as microelectrode array and field effect transistor array can be settled easily. Based on the theoretical analysis of the interface between cells and LAPS, spontaneously discharges of hippocampal neurons induced by Mg^2＋-free media treatment were recorded by LAPS. The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.

关 键 词：NEUROCHIP cell-based biosensor hippocampal neurons light-addressable potentiometric sensor 

分 类 号：TG[金属学及工艺]