新兵进驻高原后血清IL-6、TNF-α和DPD浓度测定分析  

Determination of Serum Level of IL-6 and TNF-α and density of Urine DPD in the Soldiers Exposed to High Altitude

作　　者：白孟海[1] 葛宝丰[1] 高文魁[2] 邓永忠[2] 李万平 张晓红[1] 郑荣[1] 

机构地区：[1]兰州军区兰州总医院,730050 [2]西宁解放军第四医院,810007 [3]青海武警总队海北州支队,810300

出　　处：《高原医学杂志》2006年第4期22-24,共3页Journal of High Altitude Medicine

基　　金：全军科研基金课题(编号:01Z008)

摘　　要：目的:探讨高原环境对骨代谢的影响,测定与骨代谢相关细胞因子白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)和尿脱氧吡啶酚(DPD)的浓度变化。方法:应用放射免疫法和化学发光法,对160名进驻海拔3 000m地区3个月后的新兵血清进行IL-6、TNF-α和尿DPD含量测定。并同平原(海拔1400m)组进行对照。结果:进驻高原地区3个月后新兵的血清IL-6、TNF-α和尿DPD排泄浓度均显著高于平原组P<0.01,分别为90.58±46.85、1.18±1.62和115.20±66.86。结论:由平原进驻高原3个月后,因受环境等因素的影响,可导致骨代谢相关因子血清IL-6、TNF-α和尿DPD排泄增加。Objective： To discuss the effect of high altitude environment on bone metabolism and determine the change of serum level of IL-6 and TNF-α and density of urine DPD. Methods： 160 new soldiers exposed to 3 000m altitudes from 1 400m were enrolled in the report. The serum contents of IL-6 and TNF-α and urine DPD were determined by RIA after exposed 3 000 altitudes for 3 months＇, the results were compared with the control group （1 400m altitudes）. Results： The serum dengity of IL-6 and TNF -α was 90.58±46.85pg/L, 1. 18±1.62ng/L respectively in high altitude group, arid urine DPD excretion density in the altitude group was（115. 20±66. 86）nmol/L, the results were significantlyhigher than those in the control group （P〈0. 01）. Conclusions. The high altitude environment could induce the increase of serum level of IL-6 and TNF-α and urine DPD excretion density.

关 键 词：高原 白细胞介素-6 肿瘤坏死因子 脱氧吡啶酚 骨代谢 

分 类 号：R82[医药卫生—临床医学]