吸入一氧化氮对肺挫伤的治疗作用  

The effect of inhaled nitric oxide on pulmonary contusion

作　　者：牛立志[1,2] 刘维永[1,2] 戚好文[1,2] 廖建军[1,2] 罗新林 

机构地区：[1]第四军医大学西京医院心胸外科 呼吸内科 [2]第四军医大学航空生物动力学教研室

出　　处：《第四军医大学学报》1996年第5期368-370,共3页Journal of the Fourth Military Medical University

基　　金：全军"八五"攻关课题

摘　　要：目的：研究吸入０．００８％一氧化氮（ＮＯ）对肺挫伤的治疗作用．方法：通过特制多功能撞击台撞击兔右侧胸壁，建立兔肺挫伤模型，并观察吸入ＮＯ对肺挫伤病理生理变化的影响．３２只新西兰纯种兔分为４组，每组８只：Ａ组为肺挫伤组；Ｂ组为肺挫伤加ＮＯ吸入组；Ｃ组为正常对照组；Ｄ组为单纯ＮＯ吸入组．结果：①Ａ组和Ｂ组动物与Ｃ组相比，伤后肺动脉压（ｍＰＡＰ），肺血管阻力（ＰＶＲ）及肺内分流（Ｑｓ／Ｑｔ）明显增加，而动脉血氧分压（ＰａＯ２）下降（Ｐ＜０．０１）．②Ｂ组吸入０．００８％ＮＯ气３０ｍｉｎ后，与吸入前及Ａ组相比能降低ｍＰＡＰ，ＰＶＲ和Ｑｓ／Ｑｔ（Ｐ＜０．０１），提高ＰａＯ２（Ｐ＜０．０５），而静脉血高铁血红蛋白升高不显著．③单纯吸入０．００８％ＮＯ气体对正常动物无明显影响．结论：吸入０．００８％ＮＯ对肺挫伤有一定治疗作用．Objective: To observe the effect of inhaled nitric oxide (0.008%) on pulmonary contusion. Methods: A rabbit model of pulmonary contusion was established with the impactor and the pathophysiologic changes were observed before and after inhaling NO. Thirty two New Zealand white rabbits were divided into 4 groups (group A, B, C and D): pulmonary contusion group ( n =8); pulmonary contusion with NO inhalation group ( n =8); normal control group ( n =8) and simple NO inhalation group ( n =8). Results: Group A and B show increased pulmonary vasoconstricition, pulmonary arterial pressure, physiologic shunt and decreased partial pressure of oxygen in artery (Pa O 2 ) compared with group C ( P <0.01). Group B is characterized with decreased pulmonary artery pressure, pulmonary vascular resistant index, pulmonary physiologic shunt ( P <0.01) and increased Pa O 2 ( P <0.05) compared with NO preinhalation and group A. Conclusion: Inhaled NO exerted beneficial effects on pulmonary arterial hypertension and oxygenation induced by pulmonary contusion.

关 键 词：一氧化氮 肺挫伤 血流动力学 治疗 

分 类 号：R655.305[医药卫生—外科学]