1997～2006年广州市人禽流感监测分析  

Investigation of surveillance on human infection with avian influenza in Guangzhou in 1997 to 2006

作　　者：秦鹏哲[1] 王玉林[1] 狄飚[1] 周秀珍[1] 柳洋[1] 蔡衍珊[1] 沈纪川[1] 刘于飞[1] 鲁恩洁[1] 周端华[1] 王鸣[1] 

机构地区：[1]广州市疾病预防控制中心,510080

出　　处：《微生物与感染》2006年第4期197-199,206,共4页Journal of Microbes and Infections

基　　金：广州市科技研究基金(2005Z3-E0611;2006Z3-E5141)

摘　　要：目的在禽畜饲养、销售、宰杀场所和发生人禽流感疫情的疫点开展人感染禽流感的监测,探索禽流感病毒感染人的流行病学特征。方法采集广州市禽流感相关高危人群的血清样本,用微量血凝抑制半加敏法进行检测。对监测到的H9N2阳性病例和H5N1的感染者进行流行病学调查。结果近年来广州市禽接触职业人群H9感染率为4．56％(0．51％～10．00％),各年龄组差异无显著性;H5N1患者有多个售卖活禽肉菜市场活动史,1例H9N2患者及1例H5N1感染者无直接接触禽类活动史,另1例H5N1感染者为活禽交易市场禽类宰杀人员。结论H5N1和H9N2可在相关高危人群造成隐性感染或轻症感染;除禽饲养场所外,农贸市场的活禽销售、宰杀场所也存在禽流感病毒感染的风险。Objective To understand the epidemiological features of human infections with avian influenza for those working in the avian breeding, sales and slaughtering at locations with potentially high epidemics of human case of avian influenza infections. Methods Serum samples were collected from human volunteers with high risk to avian influenza infection. Antibodies specific to avian influenza were tested by micro bemagglutination inhibition assay. Epidemiological analysis was conducted on cases potentially infected with H9N2 or H5N1. Results The H9 infection rate among the occupational group dealing with poultry in Guangzhou was 4.56% （0.51% - 10.00% ） for the period studied in this report. There was no significant difference among various age groups. One person infected with avian influenza A （ H5N1 ） at Guangzhou in 2006 had traveled to multiple live poultry markets before the onset of disease. A poultry slaughterer working in one of these live poultry market had positive anti-H5N1 antibody responses. On the other hand,one person with positive anti-H5N1 and one patient with positive anti- HgN2 did not have history of direct poultry contact. Conclusion H5N1 and H9N2 may cause asymptomatic infections in humans. Beside persons working directly in poultry farms, those involved in avian breeding, sales and slaughtering are also at high risk for avian influenza infection.

关 键 词：禽流感 抗体 监测 环境 

分 类 号：R181.8[医药卫生—流行病学]