绝经后冠心病患者雌激素水平与血脂及内皮功能的关系  

The Relationship between Blood Lipoproteins,Endothelial Function and Estrogen in Post-menopausal Women with Coronary Artery Disease

作　　者：梁春卉[1] 张晶[1] 梁伯平[1] 

机构地区：[1]天津市胸科医院心内科,300051

出　　处：《天津医药》2007年第1期18-20,共3页Tianjin Medical Journal

摘　　要：目的:探讨绝经后冠状动脉粥样硬化性心脏病(冠心病)患者血浆中内源性雌激素水平与血浆脂蛋白及内皮功能的关系。方法:以正常绝经≥1年的136例因胸部不适收住院并经冠状动脉造影的妇女为研究对象,且无雌激素替代治疗者。根据冠状动脉造影结果分为冠心病与非冠心病2组。空腹测定血浆中雌激素、各种脂蛋白、内皮素、一氧化氮、一氧化氮合酶。结果:2组间年龄、绝经年数等一般情况差异无统计学意义(P>0.05),冠心病组较非冠心病组雌二醇显著降低(P<0.01),胆固醇、甘油三酯、低密度脂蛋白明显升高(P<0.01),高密度脂蛋白显著降低(P<0.05),而内皮素明显升高(P<0.01)。结论:绝经后女性雌激素水平下降与血浆脂蛋白异常改变及内皮功能损害有关,是女性绝经期后冠心病发病率和死亡率升高的重要原因之一。Objective： To investigate the relationships of endogenous estrogen, blood lipoproteins and endothelia functions in post menopausal women with coronary artery disease （CAD）. Methods： One hundred and thirty-six normal post menopausal women （menopause ≥ lyear） were studied, all of them were admitted and undertaken coronary angiography because of complaining variable degrees of chest pain or discomfort and without adopting estrogen replacement therapy. According to the result of coronary angiography, women were divided into the coronary artery disease （CAD） group and the non-CAD （NCAD） group. The empty stomach level of estrogen （E2）, some parameters of lipid profile, endothelin, nitrogen monoxidum and nitrieoxide synthase were investigated in two groups. Results： The age,average menopausal period and common status were not statistically different between the two groups（P 〈 0.05）. The levels of E2 deereased（P 〈 0.01）,eholesterol,triglyeeride and LDL increased （P 〈 0.01）,HDL significantly decreased （P 〈 0.05） and endothelin increased （P 〈 0.01） in the CAD group compared with the non-CAD group.Conclusion： Estrogen deficiency is associated with some abnormal changes of blood lipoproteins and endothlia function in post-menopausal women. It is one of the most important factors that increase the mobility and mortality of CAD with post- menopausal women.

关 键 词：冠状动脉疾病 绝经后期 雌激素类 内皮 血管 脂蛋白类 

分 类 号：R392.12[医药卫生—免疫学]