六味地黄汤抗大鼠运动性疲劳实验研究  

The Effect of Liuwei Dihuang Decoction on Exercise-induced Fatigue in Rats

作　　者：蔡明明[1] 王蕴红[1] 张冰[2] 高顺生[3] 

机构地区：[1]首都体育学院,北京100088 [2]清华大学体育教研部 [3]广东省湛江师范学院体育系

出　　处：《中国运动医学杂志》2007年第1期56-59,共4页Chinese Journal of Sports Medicine

摘　　要：目的:观察滋阴清热补肾代表方六味地黄汤抗大鼠运动性疲劳的作用。方法:将48只SD大鼠随机分为对照组、单纯运动组、小剂量中药+运动组、大剂量中药+运动组。各运动组大鼠进行6周递增负荷游泳训练,两服药组分别以4g/kg·d和8g/kg·d剂量六味地黄汤灌胃。实验6周末处死大鼠,分别测定肝糖原、肌糖原和心肌、骨骼肌、肝脏SOD和MDA含量,取血浆测定皮质醇和睾酮含量。结果:各运动组大鼠肝糖原含量均较对照组低,但服药组大鼠肝糖原含量比单纯运动组明显增加,有显著性差异;两服药组大鼠肝脏、骨骼肌SOD活性高于单纯运动组,而MDA值低于单纯运动组;单纯运动组大鼠出现运动性血睾酮降低,而两服药组大鼠血睾酮水平与对照组相比无明显差异。结论:六味地黄汤可以提高运动大鼠肝糖原含量,改善自由基代谢,纠正降低的血睾酮水平,具有抗运动性疲劳的作用。Objective To observe the effect of Liuwei Dihuang decoction （LW） （used for ＂nourishing Yin＂ in traditional Chinese Medicine） on exercise - induced fatigue in rats. Methods Forty eight SD rats were divided into 4 groups randomly： control group （group Ⅰ ）, exercise group （group Ⅱ ）, low dose LW plus exercise group （group Ⅲ ）, high dose LW plus exercise （group Ⅳ ）. All rats except those in control group swam every day with incremental load for 6 weeks. By the end of the 6th week, all rats were killed and their plasma hormone, glycogen concentration and free radicals were determined. Results Liver glycogen concentration in both the exercise and the exercise ＋ LW groups were decreased, but the glycogen concentration in exercise ＋ LW groups was higher than that in exercise group ; SOD activity of liver tissue and muscle tissue in exercise ＋ LW groups was higher than that in exercise group, and MDA were lower in exercise ＋ LW groups. The serum testosterone level in exercise group decreased significantly, while remained unchanged in the exercise ＋ LW groups. Conclusion LW could increase the levels of glycogen in liver and testosterone in serum, and improve the anti - oxidation ability of rats with exercise - induce fatigue.

关 键 词：六味地黄汤 运动性疲劳 糖原 自由基 睾酮 

分 类 号：R285.5[医药卫生—中药学]