AQP4参与卵巢激素对单胺类神经递质的调节作用  

Role of AQP4 in the regulative effects of ovarian hormones on monoamine neurotransmitters

作　　者：张慎忠[1] 章静[1] 高琳[1] 范益[1] 孙秀兰[1] 丁建花[1] 胡刚[1] 

机构地区：[1]南京医科大学基础医学院神经药理研究室,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2007年第1期15-18,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(30572172);江苏省自然科学基金(05KJB310075)

摘　　要：目的:探讨AQP4对卵巢激素调节神经递质作用的影响。方法:应用雌性AQP4基因敲除型CD1小鼠与野生型CD1小鼠,测定AQP4基因敲除对小鼠血浆中雌孕激素水平的影响;两种基因型小鼠实施卵巢去势手术(OVX),测定纹状体和皮层中单胺类神经递质的含量。结果:AQP4基因敲除型小鼠动情后期血浆雌、孕激素水平显著低于野生型小鼠;去势后野生型小鼠纹状体多巴胺(DA)及皮层去甲肾上腺素(NE)含量明显降低,但去势不影响AQP4基因敲除型小鼠脑内相应的递质水平。结论:AQP4参与了卵巢激素对单胺类神经递质的调节。Objective：To investigate the effects of AQP4 on the interplay between sex hormone and neurotransmitter. Methods：Firstly, the concentrations of estrogen and progestogen between AQP4 knockout and wild type female mice were compared. And then the alterations of monoamine neurotransmitters in ovariectomied female mice were determined. Results：AQP4 knockout decreased the concentrations of estrogen and progestogen. Ovariectomy only induced the decrease of DA in striatum of AQP4^＋/＋ mice, but did not alter the levels of DA in AQP4^-/- mice. Conclusion：These findings reveal for the first time that AQP4 alters the action of ovarian hormones on monoamine neurotransmitters.

关 键 词：AQP4 基因敲除 单胺类递质 卵巢激素 OVX 

分 类 号：R338[医药卫生—人体生理学]