经鼻持续气道正压通气对阻塞性睡眠呼吸暂停低通气患者血清脂联素和血压的影响  

Effects of nasal continual positive airway pressure on serum adiponectin and mean arterial pressure in patients with obstructive sleep apnea hypopnea syndrome

作　　者：吴睿[1] 张希龙[1] 

机构地区：[1]南京医科大学第一附属医院呼吸内科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2007年第1期36-38,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:探讨在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者中持续气道正压通气(NCPAP)对血清脂联素和血压的影响,以及血清脂联素水平和高血压之间可能存在的相关关系。方法:选择23例男性中、重度OSAHS患者,于NCPAP治疗前1天和NCPAP治疗中、后检测血清脂联素、平均动脉压(MAP)。结果:OSAHS患者接受NCPAP治疗后,血清脂联素水平逐渐升高而MAP逐渐降低;血清脂联素水平和MAP显示与NCPAP治疗前相比,NCPAP治疗的第3天和第7天均未见统计学差异(均为P>0.05),但在NCPAP治疗的第14天差异显著(P<0.01)。结论:OSAHS可引起低脂联素血症,后者可能参与了OSAHS并发高血压的发病,且可被NCPAP治疗所纠正。Objective：To investigate the effects of nasal continualpositive airway pressure（NCPAP） on adiponectin and mean arterial pressure （MAP） in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods：The effects of NCPAP therapy on serum adiponeetin and MAP levels were observed in 23 patients with moderate or severe OSAHS before and on the 3rd, 7th,14th day of NCPAP treatment. Results：Adiponectin levels were significantly higher in patients 14 days after treatment with NCPAP（P 〈 0.01 ）. MAP level was significantly lower in patients on 14th day of NCPAP treatment （P 〈 0.01 ）. Conclusion：The results suggest OSAHS could cause hypoadiponectinemia, which might be involved in the pathogenesis of hypertension in OSAHS patients and might be reversed by NCPAP therapy.

关 键 词：持续气道正压通气 阻塞性睡眠呼吸暂停低通气综合症 血清脂联素 平均动脉压 

分 类 号：R563.8[医药卫生—呼吸系统]