2型糖尿病与恶性肿瘤临床相关性的研究  

Study on the clinical relationship of type 2 diabetes with malignant tumor

作　　者：王爱萍[1] 刘超[2] 庞春梅[1] 薛颖[2] 饶亚平[1] 蒋克春[1] 

机构地区：[1]解放军第454医院内分泌科,江苏南京210002 [2]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2007年第1期55-58,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:从临床的角度探讨2型糖尿病与恶性肿瘤的相关性及临床意义。方法:调查了2000￣2005年资料相对完整的所有含有2型糖尿病的死亡患者,据恶性肿瘤的存在与否分为肿瘤组(MG)和非肿瘤组(NMG),比较两组之间人数构成、性别、糖尿病病程、血压以及部分血生化学检查等指标,同时分析了肿瘤的发病率和分布情况。结果:2型糖尿病患者终末期平均年龄(73.57±10.17)岁,恶性肿瘤发生率高达28.35%(57/201);消化道肿瘤、血液系统肿瘤、肺癌占据前3位,收缩血压、HOMA-IR、血浆胰岛素、甘油三脂等水平升高。结论:2型糖尿病好伴发恶性肿瘤,且有其特殊的分布规律。恶性肿瘤确切的发病机制尚不明确,胰岛素抵抗可能是其原因之一。Objective：To investigate the clinical relationship of type 2 diabetes with maligant tumor. Methods：The dead patients with type2 diabetes were stratified into 2 groups according to whether they suffered from maligant tumor. The number, sex, the course of diabetes, blood pressure and some biochemical results were compared between the two groups, meanwhile the incidence and the sorts of tumor were analysied. Results：The average dead age of the patients with diabetec mellitus was （73.57 ± 10.17） years. The incidence of malignancy among the patients was 28.35%（57/201 ）. The top three kinds of maligancy were digestant cancer, hematal cancer and lung carcinoma. The systolic blood pressure, HOMA-IR, plasma insulin and triglyceride were increased. Conclusion ：Type 2 diabetes mellitus is correlated with malignancy which has special distributing rule.The pathogenesis of cancer is unclear, and insulin resistance may be involved in it.

关 键 词：2型糖尿病 恶性肿瘤 相关性 临床特点 

分 类 号：R587.1[医药卫生—内分泌] R730.2[医药卫生—内科学]