银杏叶提取物治疗慢性乙型肝炎肝纤维化病人32例  

Study of Ginkgo biloba extract in treatment of 32 patients with liver fibrosis due to chronic hepatitis B

作　　者：王京[1] 主余华[1] 任万华[1] 张春清[1] 马艳丽[1] 

机构地区：[1]山东大学山东省立医院消化内科,山东济南250021

出　　处：《中国新药与临床杂志》2007年第1期44-47,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：山东省博士基金(03BS016)

摘　　要：目的：探讨银杏叶提取物(GbE761)对慢性乙型肝炎病人肝组织纤维化的影响。方法：将60例慢性乙型肝炎病人分为GbE761治疗组32例,年龄(34±s 13)a,16～55 a及对照组28例,年龄(34±14)a,17～57a,对照组给予常规治疗,治疗组给予常规治疗加GbE761 20 mL,静脉滴注,每日1次,共4 wk,治疗前后分别检测肝功能、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)、透明质酸(HA)、层黏蛋白(LN)和转化生长因子β_1(TGF-β_1)。治疗组中5例分别于治疗前后进行肝活检术并行病理组织学检查。结果：治疗后2组的肝功能水平均较治疗前显著好转,但2组比较无差异(P>0．05)。治疗组治疗后PCⅢ,CⅣ,HA,LN及TGF-β_1水平分别下降(139±65)μg·L^(-1),(90±41)μg·L^(-1),(84±51)μg·L^(-1),(93±33)μg·L^(-1),(27±7)μg·L^(-1)(P<0．01),而对照组PCⅢ,CⅣ,HA,LN及TGF-β_1水平无明显变化(P>0．05)。治疗组5例肝活检证实,治疗后肝脏纤维化程度减轻,细胞损伤减轻。结论：GbE761对慢性乙型肝炎有显著的抗肝纤维化作用。AIM： To evaluate the effects of Ginkgo biloba extract （GbE761） on liver fibrosis in patients with chronic hepatitis B. METHODS： Sixty patients with chronic hepatitis B were divided into two groups： treatment group （n = 32） and control group （n = 28）. All were under common treatment of protecting liver and the former added with GbE761 20 mL, iv drip qd. The course of treatment for both groups was 4 wk. Liver functions, serum precollagen type Ⅲ, Ⅳ-type collagen, hyaluronate （HA）, laminin （LN） and transforming growth factor-β1（TGF-β1） levels were measured before and after the treatment. And five patients of the treatment group were furthermore taken liver biopsy before and after the treatment. Pathological changes of liver collagen, reticular fibrous tissue were detected by HE staining. RESULTS： After treatment, the indexes of liver function showed obvious improvement in both groups, and there were no significant differences between the two groups. Serum precollagen typeⅢ, Ⅳ-type collagen, hyaluronate （HA）, laminin （LN） levels and plasma TGF-β1 levels in the treatment group decreased by （139±s 65）μg·L^-1, （90 ± 41） μg·L^-1, （84 ± 51）μg·L^-1, （93 ± 33） μg·L^-1, （27 ± 7） μg·L^-1 （P 〈 0.01） respectively after the treatment, but no difference was shown in those of the control group （P 〉 0.05） . Collagen fibrous proliferation of five patients lessened in the treatment group. CONCLUSION： GbE761 possesses significant role of anti-fibrosis on liver in patients with chronic hepatitis B.

关 键 词：肝炎 乙型 慢性 细胞外基质 转化生长因子Β 银杏叶提取物 

分 类 号：R975[医药卫生—药品] R657.31[医药卫生—药学]