动脉壁切应力在颈动脉狭窄中的作用  

The Effect of Arterial Wall Shear Stress on Carotid Stenosis

作　　者：李黔宁[1] 杨益明[1] 刘勇[1] 帅杰[1] 

机构地区：[1]第三军医大学新桥医院神经内科,重庆400037

出　　处：《中国医学物理学杂志》2007年第1期48-51,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金资助项目(编号:39970269)

摘　　要：颈动脉分叉部动脉粥样硬化梗阻性疾病的起始与进展的血液动力学机制,在过去数十年被广泛研究。注意力集中在发现斑块最多的颈动脉球部或窦部。本文作者综述了颈动脉分叉部复杂的局部血液动力学改变,也包括了血液动力学改变所引起的特殊的细胞生物学反应的主要进展。这对于我们理解颈动脉窦部粥样硬化的血液动力学机制,改善血管内微创治疗与非创伤性治疗具有一定意义。Hemodynamic mechanisms for the initiation and progression of carotid bifurcation atherosclerotic occlusive disease have been extensively researched during the past decades. Attention has focused on the carotid bulb,or sinus,where most atherosclerotic plaques are found. Herein, the authors review the seminal works that have led to an understanding of not only complex local hemodynamics but also the elicited specific biologic response.Understanding the role of hemodynamics in atherogenesis may lead to the improvement of minimally invasive endovascular therapy and noninvasive strategies.

关 键 词：颈动脉狭窄 动脉壁切应力 

分 类 号：R318.01[医药卫生—生物医学工程] R543.4[医药卫生—基础医学]