精子抗原对RSA者和不孕症患者外周血单个核细胞产生IgE的影响  

Effect of Sperm Antigen on Specific IgE Produced by PBMC in Patients with Recurrent Spontaneous Abortion and Infertility

作　　者：王艾丽[1] 穆会君[1] 熊华[1] 江舟[1] 

机构地区：[1]南京军区南京总医院检验科,江苏南京210002

出　　处：《标记免疫分析与临床》2006年第4期225-226,245,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨精子抗原(SAg)对反复自然流产(RSA)者和不孕症患者外周血单个核细胞(PBMC)产生IgE的影响。用ELISA法分别测定36例RSA者,34例不孕症患者和22名正常妊娠者血清IgE和PBMC与SAg培养液中IgE水平。结果表明,血清IgE水平大于150 IU/mL的RSA者和不孕症患者与血清IgE水平≤150 IU/mL患者及早孕对照者相比,PBMC经SAg刺激后,培养液中IgE水平显著升高,提示SAg可诱导部分RSA和不孕症患者产生特异性IgE,这可能在RSA者和不孕症的发病机理中起一定作用。To study effect of sperm antigen（SAg） on IgE production by PBMC in patients with recurrent spontaneous abortion and infertility, IgE levels in serum and supernatant produced by SAg-induced PBMC were detected by ELISA in patients with RSA （n=36）, infertility（n=34） and nomal gravida （n=22）. Results showed that IgE levels in supernatant produced by SAg stimulated PBMC in RSA and infertility patients with IgE levels in serum more than 150IU/mL were significantly higher than those IgE levels in serum were less than 150IU/mL. It can be concluded that the abnormal elevation of IgE level in certain patients with RSA and infertility may be specially induced by SAg and it may play a certain role irl pathogenesis of RSA and infertility.

关 键 词：精子抗原 IGE 反复自然流产 不孕症 

分 类 号：R711.6[医药卫生—妇产科学] R714.2[医药卫生—临床医学]