固体脂质微颗粒表面稳定剂的分布状况对其稳定性的影响:介观模拟与实验  

Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments

作　　者：章莉娟[1] 龙春霞[1] 钱宇[1] 刘磊[1] 

机构地区：[1]华南理工大学化工学院,广东广州510640

出　　处：《化工学报》2007年第1期181-189,共9页CIESC Journal

基　　金：国家自然科学基金项目(20476033;20376025;20536020);国家杰出青年基金项目(20225620);广东省自然科学基金项目(0402121)~~

摘　　要：用耗散粒子动力学(DPD)方法研究了稳定剂在负载布洛芬的固体脂质微颗粒(solid lipid microparticles,SLM)表面的分布状况。模拟结果表明:以卵磷脂为稳定剂,当布洛芬的摩尔分数为1%和2%时,卵磷脂较好地包覆在颗粒的表面;而当布洛芬的摩尔分数增大到3%和5%时,卵磷脂不能覆盖在布洛芬分子密集的部位。以poloxamer 407和PVA为稳定剂,随着布洛芬摩尔分数由1%增大到5%,稳定剂都能很好地包覆在颗粒的表面。实验现象较好地吻合了模拟结果。采用DPD模拟方法,可以加深了解多相复杂载药体系的微观结构并对实验现象进行分析,为SLM稳定剂的筛选提供理论指导。Dissipative particle dynamics （DPD） simulation was used to model the distribution of stabilizers （lecithin, poroxamer and PVA） on the surface of ibuprofen-loaded solid lipid microparticles （SLM） . It was shown from DPD simulation results that lecithin totally enwrapped the surface of SLM when the molar fraction of ibuprofen was 1% and 2 %. However, when the molar fraction of ibuprofen was increased to 3 and 5 %, lecithin could not cover the place with a higher concentration of ibuprofen molecules. Poloxamer 407 and PVA totally enwrapped the surface of SLM when the molar fraction of ibuprofen was increased from 1% to 5 %. The experimental results could be interpreted with the simulation results. DPD simulation provides an insight into the microstructure of a drug carrier and helps to analyze the experimental results, which is helpful in stabilizer selection for SLM.

关 键 词：耗散粒子动力学 介观模拟 稳定剂 固体脂质微颗粒 

分 类 号：TQ423.12[化学工程]