温胃舒冲剂对小鼠慢性萎缩性胃炎的保护作用及其机理初探  

Protective effects of Wenweishu chongji on chronic actrophic gastritis in mice and its therapeutical mechanism

作　　者：杨耀芳[1] 王钦茂[1] 张伟媚[1] 樊彦[1] 陈艳荣 

机构地区：[1]安徽中医学院药理教研室,合肥230038

出　　处：《中国中西医结合脾胃杂志》1996年第4期221-224,共4页

摘　　要：温胃舒冲剂是根据临床实践组成的中药复方制剂．为了探讨其作用机理．用小鼠造成３种模型：去氧胆酸钠（ＤＯＣＡ）造成慢性萎缩性胃炎（ＣＡＧ）模型；ＤＯＣＡ＋甲疏基咪唑造成 ＣＡＧ－阳虚模型，ＤＯＣＡ＋甲状腺＋利血平造成 ＣＡＧ－阴虚模型。以血浆中环磷酸腺苷（ｃＡＭＰ ）、环磷酸鸟苷（ｃＧＭＰ）观察其治疗作用。结果表明，温胃舒能降低ＣＡＧ模型小鼠的ｃＡＭＰ、ｃＧＭＰ．也能降低ＣＡＧ－阳虚模型小鼠的ｃＧＭＰ，与模型对照组比较均Ｐ＜０．０５～０．０１。此外．结果还表明温胃舒冲剂有镇痛、抗炎和抑制胃肠推进运动、并能提高大鼠淋巴细胞转化率、血清ＩｇＧ水平。Wenweishu (WWS ) chongji is basically composed of Chinese meteria medica according to TCM thery and clinical practice. In order to elucidate its mechanism of action. three type model were in mince : chronic atrophy gastrits (CAG ) model was induced by DOCA;CAG- yang dificiency model was induced by DoCA+ thiamazoli ; CAG-yin dificielley model was induced by DOCA + thyroder --reserpine. The effects of WWS on the plasma cAMP. cGMP level was observed. The results showed that CAG model mice had a significant decrease in cAMP, cGMP. CAG-yang difieiency model mice significantly decreased in cGMP, compared to control group (P < 0. 05 ). In addition, WWS shown anaigcsia. anti-inflarnmantion inhibiting gastrointestinal movement of mice and improving immune function of rats.

关 键 词：慢性 萎缩性胃炎 温胃舒冲剂 中药品 中医药疗法 

分 类 号：R259.733.2[医药卫生—中西医结合] R286[医药卫生—中医内科学]