四种药物联合检测对2型糖尿病早期肾损伤诊断的探讨  

The Analysis on Early Diagnosis of Diabetic Nephropathies by Mutiple Tumor Markers with Urinary mALB、α_1-MG、β_2-MG and NAG

作　　者：叶晓涛[1] 许瑞环[1] 廖长征[1] 何国坚[1] 尹学念[1] 

机构地区：[1]深圳市龙岗中心医院,广东深圳518116

出　　处：《实用医技杂志》2007年第2期163-165,共3页Journal of Practical Medical Techniques

摘　　要：目的：探讨尿微量白蛋白（mALB）、α1-微球蛋白（α1-MG）、β2-微球蛋白（β2-MG）和N-乙酰-β-D氨基葡萄糖苷酶（NAG）联合检测对5年以上病程2型糖尿病（NIDDM）患者肾损伤早期诊断的价值。方法：采用免疫透射比浊法和比色法检测80例2型糖尿病患者及60例健康体检者晨尿mALB、α1-MG、β2-MG和NAG含量。结果：2型糖尿病患者尿mALB、α1-MG、β2-MG、NAG水平均显著高于对照组（P〈0．01）。NIDDM患者中，尿α1-MG增高的阳性率为37．5％，4项指标的单项或联合检测的敏感性远远高于常规尿蛋白测定，单项检测的阳性率较低，联合检测阳性率较高，其中α1-MG＋β2-MG＋NAG模式高达57．5％，4项联检阳性率达63．75％。结论：尿mALB、α1-MG、β2-MG和NAG是NIDDM患者早期肾损害的敏感指标，联合检测3项～4项指标有较高的阳性率，对于2型糖尿病患者早期肾损伤诊断有一定的临床意义。Objective To study the role of combined urinary mALB ,α1-MG,β2-MG and NAG for diagnosis of early renal disease with more than 5 years in type 2 diabetes mellitus. Methods by determine 80 type 2 diabetes mellitus patients and 60 normal persons urinary mALB,α1 -MG,β2-MG and NAGwith Immunoturbidimetric and Colorimetry assay. ReSults The levels of urinary mALB,α1-MG,β2-MG and NAG type 2 diabetic group were higher than those in the control（P 〈0.01 ）. Positive rate of α1 -MG was 37. 5%, Positive rate of the three items together（ α1-MG ＋ β2-MG ＋ NAG） were 57.5% and the four items together were 63.75%. Conclusion Urinary mALB,α1-MG,β2-MG and NAG is sensitive and reliable for diagnosis of early renal disease , Positive rate of determine three or four together were higher and for diagnosis of early renal＇disease in type 2 diabetes mellitus have clinical significance.

关 键 词：微量白蛋白 Α1-微球蛋白 Β2-微球蛋白 N-乙酰-B-D氨基葡萄糖苷酶 2型糖尿病 

分 类 号：R587.2[医药卫生—内分泌]