均匀设计优化制备槲皮素固体脂质纳米粒  

Optimization of Preparation Techniques of Quercetin Solid Lipid Nanoparticles by Uniform Design

作　　者：李厚丽[1] 翟光喜[1] 马玉坤[2] 李凌冰[1] 

机构地区：[1]山东大学药学院,山东济南250012 [2]济南第二人民医院药剂科,山东济南250002

出　　处：《食品与药品》2007年第02A期1-3,共3页Food and Drug

基　　金：山东省优秀中青年科学家奖励基金课题(2004BS03019);山东省科技攻关立项课题;山东省卫生厅立项课题

摘　　要：目的制备槲皮素固体脂质纳米粒。方法采用高温乳化-低温固化法制备槲皮素固体脂质纳米粒,以包封率为考察指标,均匀设计法优化处方与制备工艺。结果按最优工艺条件制得的纳米粒均匀圆整,粒径为(203±75)nm,包封率为48.5%。结论优选的槲皮素固体脂质纳米粒制备工艺稳定可行。Objective To prepare quercetin-loaded solid lipid nanoparticles（QT-SLN）. Methods The QT-SLN was prepared by emulsification at a high temperature and solidification at a low temperature. The optimum formulation and preparation technique of the QT-SLN were selected by uniform design with the entrapment efficiency as the evaluation parameter. Results The QT-SLN prepared in the optimized formulation was even and regular in appearance with particle diameter of （203 ± 75） nm and entrapment efficiency of 48.5%. Conclusion The optimized QT-SLN technique is stable and feasible.

关 键 词：槲皮素 固体脂质纳米粒 均匀设计 

分 类 号：R931.71[医药卫生—生药学]