烫伤膜体外透皮吸收的实验研究  

Study on in vitro percutaneous absorption of Scald Film

作　　者：徐康康[1] 李嵘[1] 陈刚[1] 

机构地区：[1]南京医科大学附属南京儿童医院,江苏南京210008

出　　处：《儿科药学杂志》2007年第1期14-15,共2页Journal of Pediatric Pharmacy

基　　金：南京医科大学科技发展基金资助项目研究计划(NY98046)

摘　　要：目的:考察烫伤膜的体外透皮吸收效果。方法:采用半透膜作为渗透屏障,研究烫伤膜及烫伤油的皮肤渗透作用。结果:烫伤膜可透过半透膜,释药动力学方程:Q=-2.4895t2+89.372t,r=0.9108。烫伤油24h未能测出大黄素含量。结论:烫伤膜中大黄素具有较好的透皮效果。Objective：To study in vitro percutaneous absorption of Scald Film. Methods： Using semipermeable membrane as barrier to permeation, the penetrate effect of scald film and scald oil was observed. Results： Scald Film could pass the semipermeable membrane. The permeation process of scald fdm was found to follow zero-order kinetics, Q = - 2.4895 t^2 ＋ 89.372t, r = 0.9108. Scald oil couldn＇t pass the semipermeable membrane within 24 hours. Conclusions： Scald fdm has good percutaneous permeability.

关 键 词：烫伤膜 烫伤油 透皮吸收 

分 类 号：R944.9[医药卫生—药剂学]