慢性前列腺炎/盆腔疼痛综合征患者白细胞雄激素受体的改变及意义  

Changes of androgen receptor in peripheral leukocytes in patients with chronic abacterial prostatitis/chronic pelvic pain syndrome

作　　者：余秋健[1] 梁朝朝[1] 徐师国[2] 张小马[1] 郝宗耀[1] 张贤生[1] 

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230022 [2]安徽医科大学

出　　处：《山东医药》2007年第3期19-21,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30471724)。

摘　　要：目的探讨慢性前列腺炎/盆腔疼痛综合征(CP/CPPS)的发生与性激素及雄激素受体(AR)的关系。方法采用放射配体结合分析法检测78例CP/CPPS患者(CP/CPPS组)和32例正常对照者(对照组)外周血白细胞AR,同时采用放射免疫法检测患者血清睾酮(T)和雌二醇(E2)水平。结果CP/CPPS组与对照组血清E2和T水平无差异,外周血白细胞AR含量CP/CPPS组低于对照组(P<0.01),CP/CPPS组E2/T高于对照组,P<0.05。CP/CPPS患者CP症状指数评分(CPS I)与白细胞AR含量呈负相关(r=-0.512,P<0.01。结论CP/CPPS的发生、发展与E2、T比例失调及白细胞AR下调有密切的关系。[Objective] To investigate the relations between changes of sexual hormones and androgen receptor and the occurrence of chronic abacterial prostatitis/chronic pelvic pain syndrome（CP/CPPS）. [Methods] Specific binding capacity of androgen receptor in peripheral leukocytes （AR） was measured by radioligand binding assays in 78 patients with CP/CPPS（group CP/CPPS）and 32 controls（group control）,and levels of testosterone （T） and estradiol（E2） were also detected by radio immunassay. [Results] There was no significant difference between the patients and normal controls in the levels of T and E2,but the binding capacity of AR in patients was lower than that in the controls（ P 〈 0.01）. E2/T in the patients was significantly higher than that in controls（ P 〈0.05）. There was negative correlation between the severity of symptoms in the patients and the binding capacity of AR（ r =-0. 512, P 〈 0.01）. [Conclusion] The changes of AR and E2/T were involved in the pathogeny and development of CP/CPPS.

关 键 词：前列腺炎 白细胞 雄激素 雄激素受体 

分 类 号：R697[医药卫生—泌尿科学]