活性磷脂抗皮肤老化的实验研究  

Experimental study of anti-ageing effect of active phospholipids on skin

作　　者：夏锦明[1] 张颖[1] 康廷国[1] 张振杰[2] 苗杰[3] 

机构地区：[1]辽宁中医药大学,沈阳110032 [2]沈阳东新药业有限公司,沈阳110032 [3]中国医科大学附属第四医院,沈阳110032

出　　处：《实用药物与临床》2007年第1期7-8,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨活性磷脂延缓小鼠皮肤老化的作用及其机理。方法小鼠每日颈背部皮下注射D-半乳糖(1 000 mg/kg)造成小鼠老化模型,同时灌胃活性磷脂42 d后,去背部皮肤,用分光光度法测定小鼠皮肤中胶原蛋白的含量。结果活性磷脂使D-半乳糖所致的小鼠皮肤老化模型中各剂量组胶原蛋白含量均显著增加。结论活性磷脂可提高皮肤中胶原蛋白含量,提示活性磷脂具有延缓皮肤老化的作用。Objective To study the anti-ageing effect and mechanism of active phospholipids on skin, Methods The aging mice model were established by subcutaneous administration with a dose of D-galactose [1000 mg/（kg·d）] for 6 weeks. Then all the mice received active phospholipids by intragastric administration. After 42 d, the contents of collagen in mice back skin were measured by photometry. Results The contents of collagen in all do6es of active phosopholipids mice＇ s skin were increased obviously, Conclusion Active phospholipids could increase the contents of collagen in skin, and its anti-ageing effects is good.

关 键 词：活性磷脂 延缓老化 皮肤 

分 类 号：R751[医药卫生—皮肤病学与性病学]