怀化地区影响高血压病人治疗的药物相关基因分布及其检测  

Distribution and detection of genes related to drugs therapy in hypertensive patients

作　　者：俞群军[1] 杨丽君[2] 毛艳梅[2] 汪赛赢[2] 唐强[1] 刘昭前[2] 刘利辉[2] 周宏灏[2] 

机构地区：[1]怀化医专附属医院暨怀化市第三人民医院,湖南怀化418000 [2]中南大学临床药理研究所,湖南长沙410078

出　　处：《中国现代医学杂志》2007年第2期175-179,182,共6页China Journal of Modern Medicine

摘　　要：目的研究高血压治疗的药物相关基因细胞色素P450酶(CYP)CYP2D6、β1肾上腺素受体、CYP2C9、血管紧张素AT1受体和血管紧张素转换酶(ACE)在高血压病人中的分布情况。方法采用聚合酶链式反应-限制性片断长度多态性方法(PCR-RFLP)对高血压病人进行基因型分析。结果对126名高血压病人CYP2D6、β1受体、AT1受体、ACE进行基因型分析,发现高血压人群中CYP2D6*10突变188位T等位基因、β1受体突变389位1165位C等位基因、CYP2C9*31061位C等位基因、AT1受体突变1166位C等位基因、ACE插入I等位基因和缺失D等位基因的分布频率分别为61.5%,71.8%,1.6%,7.9%,75.0%和25.0%。结论该研究结果显示高血压人群中CYP2D6188位T等位基因和AT1受体1166位C等位基因的频率高于正常人群,而ACE缺失D等位基因频率较正常人群低。[Objective] To investigate the distribution of genes related to drugs therapy in the hypertensive patients. [Method] Genotypes analysis was performed using Polymerase Chain Reaction-Restrict Fragment Length Polymorphism （PCR-RFLP）. [Result] In 126 hypertensive patients, the frequencies of 188T for CYP2D6＊10, 1165C for 61 adrenergic receptor, CYP2C9＊3, 1166C for AT1 receptor, ACE IfD were 61.5%, 71.8%, 1.6%, 7.9%, 75.0%, and 25.0%, respectively. [ Conclusion] These data suggest that the frequencies of 188T for CYP2D6＊10 and 1166 C for AT1 receptor in hypertensive patients are higher than that in healthy populations, but the frequency of ACE D allele is lower than that in healthy populations.

关 键 词：Β1肾上腺素受体 CYP2D6 CYP2C9 AT1 ACE 高血压 

分 类 号：R969[医药卫生—药理学] R971[医药卫生—药学]