哮喘患儿血清可溶性细胞间黏附分子-1水平的检测研究  

Study on serum concentration of soluble intercellular adhesion molecule-1 determination in children with Bronchi asthma

作　　者：齐静姣[1] 张平[2] 任新乐[2] 

机构地区：[1]河南科技大学医学院免疫学教研室,河南洛阳471003 [2]河南科技大学第三附属医院,河南洛阳471003

出　　处：《中国现代医学杂志》2007年第2期180-182,共3页China Journal of Modern Medicine

摘　　要：目的进一步探讨可溶性细胞间黏附分子-1(sICAM-1)在支气管哮喘中的作用。方法采用放射免疫测定法对48例支气管哮喘发作期患儿及26例正常对照组儿童血清sICAM-1的水平进行检测。结果支气管哮喘儿童血清sICAM-1水平在急性期和缓解期均较正常对照组升高,差异有显著性(P<0.05)。重度哮喘发作儿童较轻、中度发作升高具显著性(P<0.01)。结论sICAM-1可能参与了哮喘的发生与发作,其水平的高低可能与哮喘的活动度有关,提示sICAM-1可视为判断病情严重程度的重要指标之一。[Objective] To furtherty explore the effect of soluble intereeUular adhesion molecule-1 （sICAM-1） in pathogenesis of children with Bronchi asthma. [Methods] 48 asthmatic children and 26 healthy subjects were ineluded in the study. The concentration odd sICAM-1 in the sera was measured by the radioimmunoassay. [Results] The level of sICAM-1 was greatly increased in asthmatic acute attack and remission period than control group （P 〈 0.05）. The level was also greatly increased in severe asthmatic acute attacks than in mild or moderate attacks （P 〈 0.01）. [Conclusions] sICAM-1 may play a prominent role in the pathogenesis of asthma, and the serum level of it may reflect the activity of asthma, it serves as an important index in judging the severity of asthma.

关 键 词：儿童 支气管哮喘 SICAM-1 

分 类 号：R562.25[医药卫生—呼吸系统]