中药猫爪草有效部位的免疫活性研究  

Study on Immunocompetence of Active Constituent of Radix Ranunculi Ternati

作　　者：张振凌[1] 吴筱菁[1] 王磊[1] 张惠霞[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中华中医药杂志》2007年第2期120-122,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河南省重大科技攻关课题(No.0522030200)

摘　　要：目的:确定猫爪草有效部位对实验动物免疫功能的影响。方法:环磷酰胺造模法制作免疫抑制小鼠模型,灌胃给药,观察和比较猫爪草多糖、皂苷对其腹腔巨噬细胞吞噬功能、溶血素形成以及外周血T淋巴细胞数的影响。结果:猫爪草多糖、皂苷可使吞噬百分率、吞噬指数显著升高;猫爪草多糖、皂苷可显著促进溶血素的形成并提高外周血中T淋巴细胞数。结论:猫爪草的有效部位对免疫抑制小鼠有免疫兴奋作用。Objective： To determine the effects of active constituent of Radix Ranunculi Ternati on immune function of experimental animal. Methods： Immune suppression mouse models were made by cyclophosphamide method. After intragastric administration, the effects of polysaecharide and saponin of Radix Ranunculi Temati on phagocytosis of peritoneal macrophage, formation of hemolysin and T-lymphocyte population of peripheral blood were observed and compared. Results： These two active constituent can highten the percent and the index of phagocytosis, enhancement the formation of the hemolysin obviously and increase the number of T-lymphocytes in peripheral blood. Conclusion： The active part of Radix Ranunculi Ternati can stimulate the immunologic function of immune suppression mouse models.

关 键 词：猫爪草 皂苷 多糖 免疫活性 

分 类 号：R285[医药卫生—中药学]