心安颗粒对病毒性心肌炎小鼠心肌酶及病毒滴度的影响  

The effect of Xinan granules on the serum cardiac enzyme and viral concentration of viral myocarditis in mice

作　　者：陈美娟[1] 肖顺汉[1] 杨思进[1] 葛李[2] 顾立[1] 

机构地区：[1]泸州医学院药学院,四川泸州646000 [2]泸州医学院临床医学院,四川泸州646000

出　　处：《中国医院药学杂志》2007年第1期1-2,共2页Chinese Journal of Hospital Pharmacy

基　　金：四川省教育厅重点项目[编号:川教科(1998)143号];中医药管理局基金项目(编号:2000-18)

摘　　要：目的:探讨心安颗粒对病毒性心肌炎小鼠心肌酶及病毒滴度的影响。方法:采用BALB/C小鼠腹腔注射柯萨奇病毒B3(CVB3)建立小鼠病毒性心肌炎模型。小鼠随机分为空白对照组、模型组、心安颗粒10,20,40g(生药).kg-1.d-1和利巴韦林0.1g.kg-1.d-1组,注射CVB32h后给药,连续用药7d,第8天处死小鼠,取血测定血清心肌乳酸脱氢酶(LDH)及中和抗体,取心肌制成细胞悬液,测定病毒滴度。结果:心安颗粒治疗组与模型组相比,血清LDH含量明显降低,中和抗体及病毒滴度明显降低(P<0.01)。结论:心安颗粒对病毒性心肌炎小鼠具有抗病毒、缓解心肌炎症作用。OBJECFIVE To investigate the effect of Xinan granules on the serum cardiac enzyme and viral concentration of viral myocarditis in mice. METHODS Viral myocarditis model was induced by intraperitoneal inoculation with Coxsackie virus in BALB/C mice, the mice were randomly divided into six groups： the normal control group, the model control group, the Xinan granules 10,20,40 g·kg^-1·d^-1 groups and the ribavirin 0. 1 g·kg^-1·d^-1 group. After CVB3 infection 2 h, mice were given drugs for 7 days. Blood and heart samples were obtained on the 8th day after CVB3 infection. The serum cardiac enzyme（LDH）, neutralisational antibody and viral concentration were measured. RESULTS The LDH、 neutralisational antibody and viral concentration in Xinan group reduced more significantly than that of the model control group（P〈0. 01 ）. CONCLUSlON Xinan granules may have anti-viral and cardiac protective effects on viral myocarditis in mice.

关 键 词：心安颗粒 病毒性心肌炎 心肌酶 病毒滴度 BALB/C小鼠 

分 类 号：R972[医药卫生—药品]