微生态制剂对抗生素相关性腹泻预防作用的研究  

Prevention of Antibiotic-associated Diarrhea with Microecological Modulators

作　　者：曹艳菊[1] 张豫生[1] 许连壮 米晓森 王惠[1] 

机构地区：[1]解放军306医院,北京100101 [2]北京红十字急救中心,北京100083

出　　处：《中华医院感染学杂志》2007年第1期17-19,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨微生态制剂培菲康、整肠生对抗生素相关性腹泻(AAD)的预防作用。方法调查患有严重肺和(或)腹腔感染,静脉应用>2种抗菌药物连续治疗>5 d,排除慢性胃肠道疾病的出院成年患者344例作为对照组;按≤59岁及≥60岁分为两组,了解AAD发生情况;再选择符合上述条件的住院患者141例,随机分为两组,在抗感染治疗的同时,分别加用双歧杆菌/嗜酸乳杆菌/粪肠球菌制剂(培菲康)或地衣芽胞杆菌胶囊制剂(整肠生),比较分析各组≤59岁及≥60岁患者AAD的发生情况。结果对照组≥60岁患者AAD发生率(22.31%)明显高于≤59岁患者(8.88%P<0.01);在抗菌治疗同时口服培菲康或整肠生两组≥60岁患者AAD发生率均明显低于对照组。结论应用抗菌药物治疗同时,口服微生态制剂培菲康或整肠生均能有效预防AAD的发生。OBJECTIVE To investigate the prevention measures of antibiotic-associated diarrhea （AAD） with microecological modulators. METHODS As control group, 344 hospitalized adult patients with severe abdomen and/or lung infection but without gastroenteric disease received combined antibiotics treatment for more than five days. other 141 patients with same disease were divided into two test groups randomly. The patients received combined antibiotics treatment plus Bifid Triple Viable capsule （Pei-Fei-Kang） （group A） or Bacillus licheniformis capsule （Zheng-Chang-Sheng） （group B）. The incidence of AAD in two test groups compared respectively to that of control group. RESULTS In control group, the incidence of AAD for more than 60 years old patients （22.31%） was significantly higher than that of less than 60 years ones （8. 88%） （P〈0. 001）. In the patients more than 60 years, the incidence of AAD in the two test groups were both obviously lower than that of in control group. CONCLUSIONS Both Pei-Fei-Kang and Zheng-Chang-Sheng can prevent effectively incidence of antibiotic-associated diarrhea and have similar effect.

关 键 词：微生态制剂 抗生素相关性腹泻 预防 

分 类 号：R969.3[医药卫生—药理学]