百草枯中毒后大鼠血清心肌肌钙蛋白I的检测及分析  

Detection and analysis of blood serum CTnI in acute paraquat poisoning rats

作　　者：张玲[1] 营向东[2] 金立元[1] 杨红年[1] 黄琳[1] 

机构地区：[1]宁夏自治区人民医院,宁夏银川750021 [2]山东省齐鲁医院,山东济南250012

出　　处：《宁夏医学杂志》2007年第2期99-100,共2页Ningxia Medical Journal

基　　金：宁夏科技厅科技攻关项目(编号:K200404)

摘　　要：目的观察百草枯(PQ)中毒后大鼠血清心肌肌钙蛋白I(CTnI)的含量变化,并探讨CTnI与PQ中毒的关系及应用价值。方法将112只成年SD大鼠随机分为4组,对照组,高、中、低剂量组,并设6,12、247、2小时4个时相点,测定血清CTnI含量。结果高剂量PQ中毒动物CTnI明显升高(P<0.01),而中低剂量PQ中毒CTnI含量与对照组之间无显著差异(P>0.05)。结论高剂量PQ中毒均有心肌损伤,CTnI与中毒程度有高度相关性,表明CTnI在评价的PQ中毒程度及预后方面有一定价值,同时为PQ中毒早期实行保护心功能的治疗措施提供了理论依据。Objective To observe the changes for of blood senun CTnI in acute paraquat poisoning rats and to evaluate the correlation andapUication value between CtnI and PQ poisoning.Methods All 112 healthy adult Wister rats were randomly assigned into control groups, paraquat high, moderate, low dose group. It was divided into 4 observing phrases of 6h, 12h,24h, 72h and determined the content of blood serum CtnI. Results The content of blood serum CTnI was significantly higher in high dose group, and there was no significant differences between the moderate dose group and normal group,low dose group and the normal group.Conclusion The high dooe group has myocardial damage, there is obviously correlation between CTnI and poisoning degree. And it make it clear that there is invariably value in the evalution of PQ poisoning degree and prognosis,and at the same time it provide theory evience for practicing the therapeutic measure to protect heart ruction.

关 键 词：中毒 百草枯 肌钙蛋白Ⅰ 大鼠 

分 类 号：R595.4[医药卫生—内科学]