环磷酰胺对小鼠胚胎毒性影响的研究  

Embryotoxicity of Cyclophosphamide in Mice

作　　者：贾庆军[1] 周燕虹[2] 杨录军[2] 刘晋祎[2] 冯长龙[1] 郭魁亮[1] 刘天鹏[1] 

机构地区：[1]白求恩军医学院,石家庄050081 [2]第三军医大学预防医学系卫生毒理教研室,重庆400038

出　　处：《白求恩军医学院学报》2007年第1期2-3,共2页Journal of Bethune Military Medical College

摘　　要：目的探讨环磷酰胺对小鼠的胚胎毒性作用。方法采用小鼠整体致畸试验,环磷酰胺组给予环磷酰胺10mg/kg,对照组给予等容积的生理盐水。测量孕鼠体重、胎鼠体重、胎盘重量,统计胎鼠死亡率和吸收率。结果环磷酰胺组的孕鼠体重、胎鼠体重、胎盘重量较对照组显著减少(P<0.05),环磷酰胺组的胎鼠死亡率和吸收率与阴性对照组比较,有显著性增加(P<0.01)。结论环磷酰胺对小鼠有胚胎毒性作用。Objetive The embryotoxic effect of cyclophosphamide （CP） was studied. Methods 20 pregnant mice were randomly divided into two groups.Physiological saline was injected in control group,and CP （ 10 mg·kg^-1·d^-1 ） was injected in experimental group. The weight of pregnant mice, embryo mice and placenta was measured. The rates of death and absorption in mice fetuses were counted. Results After the mice given CP, the weight of pregnant mice, embryo mice and placenta was significantly reduced （ P 〈 0.05）. The numbers of absorbed and dead embryo were increased apparently（ P 〈 0.01 ）. Conclusion CP has embryotoxicity to mice.

关 键 词：环磷酰胺 胚胎毒性 小鼠 

分 类 号：R979.1[医药卫生—药品] R994.1[医药卫生—药学]