硫酸镁联合依达拉奉治疗急性脑梗死的临床观察  

Clinical observation of therapeutic effect of magnesium sulfate combined with edaravone for acute cerebral infarction

作　　者：王展航[1] 覃士明[1] 贾兰[1] 

机构地区：[1]广州中医药大学祈福医院脑病中心,广州511495

出　　处：《中华神经医学杂志》2007年第2期189-190,共2页Chinese Journal of Neuromedicine

摘　　要：目的 观察硫酸镁联合自由基清除剂依达拉奉治疗急性脑梗死的疗效。方法 60例急性脑梗死患者随机分为2组，治疗组给予25％硫酸镁联合依达拉奉治疗，对照组予香丹注射液治疗。观察治疗前后欧洲脑卒中量表（ESS）、日常生活能力量表（ADL）比较以及疗效的变化。结果 治疗后硫酸镁联合依达拉奉组较对照组ESS评分、ADL水平明显改善（P〈0．05），其疗效优于对照组（P〈0．05）。结论 硫酸镁联合依达拉奉治疗急性脑梗死能保护脑细胞，有效改善神经功能。Objective To observe the efficacy of magnesium sulfate （MgSO4） combined with free radical scavenger edaravone in the treatment of acute cerebral infarction. Methods Sixty patients of acute cerebral infarction were randomly divided into 2 groups in this study： the treatment group were given 25% MgSO4 and edaravone by intravenous drip, and the control group were treated by Xiangdan injection. ESS, activities of daily living （ADL） and therapeutic outcomes in the 2 groups were assessed before treatment and 2 weeks after treatment. Results The scores of ESS and ADL in the 2 groups were increased after treatment, but those in the treatment group was increased more dramatically, showing significant difference from those in the control group （P〈0.05）. Curative effect of treatment group was better than that of control group （P〈0.05）. Conclusion MgSO4 combined with edaravone is effective in improving the impaired nerve functions due to acute cerebral infarction.

关 键 词：硫酸镁 依达拉奉 急性脑梗死 自由基清除剂 

分 类 号：R686[医药卫生—骨科学]