检测血浆D-二聚体在下肢静脉血栓诊断中的应用  

Application of plasma D-Dimer in the diagnosis of deep venous thrombosis

作　　者：薛文成[1] 万楠[1] 罗军[1] 陈渝宁[1] 方秀菊[1] 孟冬娅[1] 

机构地区：[1]沈阳军区总医院检验科,沈阳市110016

出　　处：《实用诊断与治疗杂志》2007年第2期113-114,共2页Journal of Practical Diagnosis and Therapy

摘　　要：目的:探讨D-二聚体定量检测在下肢深静脉血栓预防诊断中的应用价值。方法:回顾分析58例深静脉血栓患者血浆D-二聚体定量检测结果,复习相关文献资料,对D-二聚体在深静脉血栓诊断中的应用进行评价。结果:Liatest法检测D-二聚体对深静脉血栓的敏感性为98.3%;观察了2例深静脉血栓患者发病前到溶栓治疗过程中血浆D-二聚体变化,1例为骨折患者,诊断深静脉血栓前1d血浆D-二聚体含量为1.26μg/mL,诊断时为1.92μg/mL;1例为心功能不全,诊断深静脉血栓前2d血浆D-二聚体含量为1.44μg/mL,前1d为2.04μg/mL,诊断时为2.28μg/mL。结论:Liatest法可作为排除诊断深静脉血栓的首选实验室筛选试验,在有易患深静脉血栓基础疾病的患者中,血浆D-二聚体含量逐渐升高有可能作为判断深静脉血栓形成的指标。Objective To evaluate the value of measuring D-Dimer for the diagnosis of deep venous thrombosis. Methods Fifty-eight patients with deep venous thrombosis were retrospectively analyzed the results of plasma D-Dimer and reviewed the related literature and the value was estimated in the diagnosis of deep venous thrombosis. Results The sensitivity of D-Dimer measured with Liatest to deep venous thrombosis was 98. 3%. Variety process of the plasma D-Dimer within two patients was observed during the treatment. The concentration of plasma D-Dimer in the patient with fracture was increased from 1.26 to 1.96 μg/mL when diagnosed as deep venous thrombosis. The other was cardia insufficiency. The results of plasma D-Dimer rose from 1.44 to 2. 04 μg/mL. Conclusion It is suggested that quantitative and automated D-Dimer assay provide a useful diagnosis for the physician for excluding deep venous thrombosis. In the patients with the diseases that are liable to deep venous thrombosis, the gradually rising concentration of plasma D-Dimer may be used to judge deep venous thrombosis.

关 键 词：静脉血栓 深静脉血栓 D-二聚体 

分 类 号：R543[医药卫生—心血管疾病]