溶血性、非溶血性肠球菌的毒力差异  

Difference of Enterococci Virulence between Hemolytic and Non Hemolytic Strains

作　　者：强华[1] 谢曼凌[1] 

机构地区：[1]福建医科大学病原生物学系,福州350004

出　　处：《福建医科大学学报》2007年第1期43-45,共3页Journal of Fujian Medical University

基　　金：福建省自然科学基金资助项目(C0510008);福建医科大学科学发展基金(FJGXY04012)

摘　　要：目的 探讨肠球菌溶血素与毒力的关系。方法 比较溶血性肠球菌在临床标本及健康人群粪便标本的检出率；比较溶血性、非溶血性肠球菌对小鼠的LD50及其对9种抗生素的敏感性。结果 临床标本肠球菌的溶血素检出率61．5％，高于健康人群粪便标本（18．4％，P〈0．05）；溶血性肠球菌的LD50[（3．9～11）×10^8cfu／mL]比非溶血性肠球菌小[（2．5～8．9）×10^10cfu／mL，P〈0．01]。除丁胺卡那、万古霉素外，溶血性肠球菌对抗生素的耐药性明显高于非溶血株。结论 肠球菌的溶血素可能与其毒力有关。Objective To investigate the relation between enterococcus hemolysin and its virulence. Methods Incidence of hemolysin of enterococci derived from clinical isolates and healthy people fecal specimens were examined respectively; LD50 and antibiotic susceptibilities were compared between hemolytic strains and non hemolytic strains. Results Strains derived from clinical isolates exhibited higher （61.5%） incidence of hemolysin than that from healthy people fecal speciments（18.4%, P〈0.05）. The LD50 of hemolytic strains [（3.9-11） 10^8cfu/mL] were at least 10-fold higher than those of non-hemolytic strains1-（2.5-8.9） 10^10cfu/mL], P〈0.01. Hemolytic strains were found to be more resistant to all the 9 antibiotics tested, except amikacin and vancomycin. Conclusion These results implied that hemolysin may contribute to the virulence of enterococci.

关 键 词：肠球菌属 溶血素类 毒力 药物耐受性 

分 类 号：R515[医药卫生—内科学]