一种金属络合性表面活性剂及其Cu(Ⅱ)配合物的合成和抗菌性  

Synthesis and Antibacterial Activity of a Complexing Surfactant and its Cu(Ⅱ) Complex

作　　者：方海林[1] 袁淑军[1] 

机构地区：[1]盐城工学院化学与生物工程学院,盐城224003

出　　处：《应用化学》2007年第2期178-182,共5页Chinese Journal of Applied Chemistry

基　　金：江苏省高校自然科学研究项目(05KJB150142)

摘　　要：以对甲酚、月桂酸、乙二胺等为原料,通过酰化、Fries重排、磺化和缩合等反应,合成了一种含席夫碱结构的新型络合性表面活性剂,合成总产率为39．2％,以该表面活性剂为配体与Cu^(2+)作用形成配合物,产率为87．6％。测定了该表面活性剂在20℃时不同浓度下的表面张力和发泡高度,结果表明该物质具有较高的表面活性,其临界胶束浓度CMC为2．5×10^(-4)mol/L,其水溶液的最低表面张力为30 mN/m;用可见分光光度法测定了该表面活性剂铜配合物在25℃0．01 mol/L硼砂缓冲溶液中的生成稳定常数β为1．91×10~8,实验表明该表面活性剂与Cu^(2+)易形成稳定的配合物;用浓度稀释法测试了该配合物对大肠杆菌、金黄色葡萄球菌和白色念珠菌的抗菌活性,实验表明该配合物对白色念珠菌的抗菌力最高,其最小杀灭浓度为96．1×10^(-6)g/mL。A new complexing surfactant with the Schiff base structure was synthesized from p-Cresol, lauric acid and ethylenediamine by reactions of acylation, fries rearrangement, sulfonation and condensation . The total synthetic yield of the surfactant was 39. 2%. The Cu^2＋ complex with this surfactant was also prepared in synthetic yield of 87.6%. The surface tension and foam height of the surfactant were tested at 20 ℃, CMC of the surfactant was 2.5 × 10^-4 mol/L, the lowest surface tension was 30 mN/m, which showed the surfactant has high surface activity . The stability constant of the complex was determined by spectrophotometric method to be 1.91 × 10^8 in borax buffer solution at 25 ℃. The experimental result revealed that the surfactant is easily coordinated with Cu^2＋ to form stable complex. Antibacterial test showed that the complex has a high antibacterial activity against E. coli, S. aureus and B. subtilis, especially against S. aureus with the minimum bactericidal concentration at 96. 1 × 10^-6 g/mL.

关 键 词：表面活性剂 铜配合物 稳定常数 抗菌性 

分 类 号：O641[理学—物理化学] O721[理学—化学]