烧伤、冲击伤和烧冲复合伤后内皮素和血管性假血友病因子含量的变化及意义  

Changes of endothelin and von Willebrand factor in rats after burn, blast and combined burn blast injuries and their significance

作　　者：屈纪富[1] 郑怀恩 林远[1] 程天民[1] 古德全[1] 闫国和[1] 徐有奇 

机构地区：[1]第三军医大学预防医学系防原医学教研室

出　　处：《第三军医大学学报》1996年第6期525-527,共3页Journal of Third Military Medical University

摘　　要：观察了单纯烧伤、冲击伤和烧冲复合伤大鼠伤后不同时间血浆和肺组织内皮素（ＥＴ）含量、肺组织血管性假血友病因子（ｖＷＦ）含量的变化，并结合３类损伤后的肺脏病理变化，探讨了伤后ＥＴ和ｖＷＦ的变化特点及其意义。结果显示本实验条件下的伤情程序依次为：烧冲复合伤＞单纯冲击伤＞单纯烧伤；３类损伤组血浆和肺组织ＥＴ含量均出现显著变化，到达峰值和下降程度各组有所不同；肺组织ｖＷＦ含量明显降低（Ｐ＜０．０５），并与肺血管内中性粒细胞数量呈显著负相关（ｒ＝－０．９５２３，Ｐ＜０．０５）。The changes of the contents of endothelin (ET) in plasma and pulmonary tissue and von Willebrand factor (vWF) in pulmonary tissue and the pathological changes of pulmonary tissue after burn, blast and combined burn blast injuries were observed to explore the characteristics and significance of the changes of ET and vWF after injuries. It was found that the contents of ET in plasma and pulmonary tissue were significantly increased ( P <0.05) while that of vWF in pulmonary tissue was significantly decreased (P<0.05). The latter was negatively correlated with the number of neutrophils in pulmonary blood vessels. The characteristics and significance of the changes of ET and vWF after injuries were also discussed.

关 键 词：复合伤 内皮素 血管性 假血友病因子 冲击伤 

分 类 号：R640.2[医药卫生—外科学]