枳术汤治疗功能性消化不良的配伍研究  

Study on Prescribed Proportion of Zhizhu Decoction for Treating Functional Dyspepsia

作　　者：李冀[1] 刘蔚雯[2] 肖洪彬[1] 李胜志[1] 胡晓阳[1] 

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040 [2]福建中医学院药学系,福建福州350003

出　　处：《中华中医药学刊》2007年第2期199-201,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：黑龙江省科技厅攻关项目基金资助(GC05C31604)

摘　　要：目的:探讨枳术汤治疗功能性消化不良(FD)的最佳配伍比例及可能的作用机制。方法:观察枳实、白术不同配伍比例对小鼠胃肠运动的影响。采用大鼠胃电节律失常模型,应用放免法测定血浆胃动素(MTL)和血管活性肠肽(VIP)。结果:枳、术3个不同配伍比例组均能显著对抗阿托品所致小鼠胃排空与肠推进抑制(P<0.01),且优于单味枳实与白术(P<0.05)。与正常组比较,模型组大鼠血浆MTL含量显著降低,VIP含量显著升高(P<0.01)。枳术1∶1组MTL显著升高(P<0.01),VIP明显降低(P<0.05)。结论:FD的发病与血浆MTL含量的降低,VIP含量的升高有关。枳实、白术配伍用于治疗FD的最佳比例是1∶1,枳术1∶1组可能通过提高血浆MTL,降低VIP含量,促进胃肠运动,达到治疗FD的目的。Objective： To investigate the best prescribed proportion of zhizhu decoction （ZD）for FD and the mechanism. Methods ： The rat model of electrogastric dysrhythmias was used. To observe the changes on the combined use of immature bitter orange and bighead actraetylodes on gastrointestinal motivation and gastrointestinal hormone in experimental rats. Changes in motilin （MTL） ,vasoactive intestional peptide （VIP）contents in peripheral blood were determined by radioimmunoassay. Results ： Different dose of ZD could promote the gastrointestinal motivation significantly （ P 〈 0.01 ）. Compared with that of the normal control group, the plasma MTL of FD rats was decreased significantly and the VIP level elevated significantly （ P 〈0.01） . Compared with that of the model group,the plasma MTL of ZD 1：1 and motilium groups were significantly higher （ P 〈 0.01 ） and the VIP level signifieandy lower （ P 〈 0.05 ）. Conclusion： The decrease of MTL and the increase of VIP are related to FD. The best prescribed proportion of ZD was 1 ： 1 for treating FD. The therapeutic mechanism of ZD 1 ： 1 might be involved in the modulation of gastroinfestinal motility via regulating the levels of MTL and VIP.

关 键 词：功能性消化不良 枳术汤 配伍 胃肠运动 胃肠激素 

分 类 号：R289.5[医药卫生—方剂学]