三磷酸腺苷敏感性钾通道在心肌缺血预适应中的作用  

The role of ATP-sensitive potassium channels in ischemic preconditionning

作　　者：王瑞英[1] 李三潭[1] 宋长杰[1] 曹萍[1] 王虹[1] 

机构地区：[1]湖北医科大学附属第二医院心内科

出　　处：《临床心血管病杂志》1996年第6期396-399,共4页Journal of Clinical Cardiology

摘　　要：采用结扎家兔左冠状动脉左室支复制心肌缺血预适应（ＩＰ）模型，研究三磷酸腺苷敏感性钾（ＫＡＴＰ）通道在ＩＰ中的作用。结果表明：ＩＰ能缩小梗塞面积和恢复再灌注期心脏功能；活化ＫＡＴＰ通道显著加强ＩＰ的作用，尤以恢复心功能为著；阻滞ＫＡＴＰ通道则抑制ＩＰ的作用。提示ＫＡＴＰ通道活化与ＩＰ作用有关。The objective of this study was to determine whether ATP-sensitive potassium channels(KATP) were involved in ischemic preconditioning(IP) in rabbit model, Area at risk,infarct size,hemodynemic variables,myocardial intracellular Na+,K+,Ca2+,Mg2+ concentration and serum SOD,MDA concentration were measured.The result showed that IP could limit infarct size and promote myocardial contractility.Activation of KATP channels exaggerated IP effect and block of KATP channels inhibited IP. This suggests that KATP channels are involved in IP.

关 键 词：三磷酸腺苷 钾通道 心肌缺血 预适应 

分 类 号：R541.405[医药卫生—心血管疾病]