基于电生理-力学复合心脏模型的右心室三维运动分析  

Three-dimensional Motion Analysis of Right Ventricular Based on an Electrophysiologic-mechanical Composite Heart Model

作　　者：夏灵[1] 叶学松[1] 霍梅梅[1] 张宇[1] 窦建洪[1] 

机构地区：[1]浙江大学生物医学工程系,杭州310027

出　　处：《生物医学工程学杂志》2007年第1期110-115,共6页Journal of Biomedical Engineering

基　　金：973计划资助项目(2003CB716106);国家自然科学基金资助项目(30370400);教育部新世纪优秀人才支持计划资助项目(NCET-04-0550)

摘　　要：在原有电生理心脏模型基础上,我们采用有限元方法和复合材料理论建立了一个电生理-力学复合双心室模型,并基于该模型对右心室心壁在收缩期的三维运动进行仿真分析。模型建立过程中,考虑了心肌的纤维旋向、心电兴奋产生的心肌收缩力。心室壁位移、最小主应变(E 3)等用来表征心室的运动。仿真结果与加标记磁共振成像的实验结果基本一致。另外,仿真结果还表明,虽然心基部位移最大,但最大收缩力却发生在心尖部,这个结果用一般的动物实验或人体实验是难以得到的。因此,电生理-力学复合双心室模型对于今后进一步评价心脏功能具有重要意义。Based on our previous electrical heart model, an electromechanical biventricular model was constructed by means of composite material theory and the finite element method. And the 3-D motion of the right ventricular wall was simulated based on this model. The orientation of cardiac fibers and myocardial contractility were taken into consideration during simulation modeling. The propagation of electrical excitation was simulated using an electrical heart model, and the resulting active forces was used to calculate the ventricular wall motion. Regional deformation and Lagrangian strain tensors were calculated during systole. Displacements, minimum principal strains were used to describe the motion of the right ventricle. The simulation results are in good accordance with results obtained from MR tagging images reported in literatures. In addition, the results also show that although the maximum displacement occurs in the base of the heart, however, the maximum contraction occurs in the apex of the heart. Such result is very difficult to be obtained by means of animal experiment or human experiment. This study suggests that such electrophysiologic-mechanical biventricular models have the important significance to be used to assess the mechanical functions of the two ventricles.

关 键 词：电生理-力学心脏模型 双心室模型 右心室 运动变形分析 

分 类 号：R318[医药卫生—生物医学工程]