妇女骨质疏松过程及运动防治模拟  

Simulation on the Process of Female Osteoporosis and Its Prevention by Physical Activity

作　　者：马宗民[1] 李淑娴[2] 朱兴华[3] 宫赫[3] 

机构地区：[1]大连大学生物医学工程研究所,大连116021 [2]大连大学院士创业院,大连116622 [3]吉林大学工程力学系,长春130025

出　　处：《生物医学工程学杂志》2007年第1期124-128,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10372034);教育部博士点基金资助项目(20020183026);大连大学科技发展基金项目

摘　　要：应用带有力学调控系统的各向异性骨再造模型结合有限元法，进行妇女骨质疏松过程及运动防治的模拟。研究结果表明：在骨量下降初始阶段，下降平缓，绝经后骨量丢失加速，60岁时，骨量下降25．84％～28．63％，80岁时，骨量下降38．50％～40．44％，运动使外荷提高10％～20％后，可使骨量增加3．05％～10．26％，上述结果与临床观察结果基本一致。证明了肌力下降是妇女骨质疏松的主要因素，绝经则加快了妇女骨质疏松的过程。运动可减缓骨质疏松。The processs of female Osteoporosis and its prevention by Physical activity were simulated using anisotropic bone remodelling model with mechanostat combining with finite element method. The results show that bone mass declines slowly at the beginning, bone loss accelerates in postmenopause and bone mass declines 25. 84%-28.63% at the age of 60 and 38.50%-40. 44% at the age of 80. Bone mass increases 3.05%-10.26% by an increase of 10%-20% in physical activity. The above results are consistent with clinical observations ,which proves that declination of mechanical usage is the primary factor leading to osteoporosis, menopause quickens the process of female osteoporosis,physical activity can decelerate it.

关 键 词：生物力学 骨质疏松 绝经 骨再造 模拟 

分 类 号：R580[医药卫生—内分泌]