饰胶蛋白聚糖的抗纤维化和抗肿瘤作用  

The Action of Decorin in Anti-fibrosis and Anti-cancer

作　　者：马伟峰[1] 谭毅[1] 蔡绍晖[2] 陈宏远[1] 杜军[3] 蔡绍皙[1] 

机构地区：[1]重庆大学生物工程学院国家教育部生物力学与组织工程重点实验室,重庆400044 [2]暨南大学药学院临床药理教研室,广州510632 [3]中山大学药学院,广州510612

出　　处：《生物医学工程学杂志》2007年第1期222-225,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30271519);高等学校重点实验室访问学者基金资助项目

摘　　要：饰胶蛋白聚糖(Decorin,DCN)属富含亮氨酸小分子蛋白多糖家族成员之一。大量证据表明:DCN通过结合并中和转化生长因子-β(TGF-β),干扰其与受体结合所致的胞外基质过度沉积,以产生抗纤维化和抑制疤痕形成的作用;DCN亦通过激活EGFR/MAPK/p21信号通路和抑制EGF-EGFR介导的促细胞增殖信号通路等机制,抑制肿瘤细胞增殖与转移。基于DCN以上两方面的生物活性,加之源于人体自身产生,其重组产品免疫原性较低,提示DCN对于慢性纤维化和肿瘤等疾病的防治具有潜在的药用开发价值。Decorin （DCN） is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-β and interfering the binding of TGF-β with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis of tumor cells by activating EGFR/MAPK/p21 signal pathway and inhibiting the cell proliferation pathway mediated by EGF-EGFR. It is suggested that the recombinant DCN had potential pharmaceutical potency in treatment of chronic fibrosis and neoplasm for its critical biological activities and low immunogenicity.

关 键 词：饰胶蛋白聚糖 表皮生长因子受体 抗纤维化 抗肿瘤 

分 类 号：R318.08[医药卫生—生物医学工程]