肌动蛋白的形态分布与细胞黏附性之间的关系  

The Relationship between Intracellular Actin Distribution And Morphology and Cell Adherence

作　　者：程超[1] 张军[2] 朱久进[1] 王远亮[1] 

机构地区：[1]重庆大学生物工程学院国家教育部生物力学与组织工程重点实验室,重庆400030 [2]重庆医科大学生物教研室,重庆400016

出　　处：《生物医学工程学杂志》2007年第1期226-229,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金重点资助项目(19732003;19872080);国家自然科学基金资助项目(19732030);高等学校重点实验室访问学者基金资助项目

摘　　要：细胞内肌动蛋白的形态和分布与细胞的黏附之间有关联。细胞中肌动蛋白纤维含量减少时,细胞易从基质上脱落。癌细胞与静态培养的细胞中肌动蛋白纤维均分布于细胞边缘,目的是伸出伪足黏附在基底上,又可以收回伪足,使细胞从基底上脱黏附。细胞在受到外力作用下,于基底上黏附/脱附时,其骨架肌动蛋白的形态与分布发生改变。不同程度的外力作用于细胞,其骨架肌动蛋白的适应性变化不同。显然细胞在基底上的黏附/脱附机制与其肌动蛋白的形态分布间的关系尚需进一步研究。It is believed that there exists some relationship between the distribution and morphology of intracellular actin and cell adherence. Cells are likely to be deteched when the quantity of actin filament decreases. Actin filaments locate in the fringe of cancer cells and cells cultured in static state, so that these filaments can stretch out and form pseudopodia to adhere to the matrix. When these cells are stimulated their pseudopodia retract so that they can easily be detached from the matrix. When external forces are exerted on cells to adhere and deadhere from the matrix, the morphology and distribution of skeleton actin will change, so as the cells＇ morphology. The skeleton actins in cells are changed differently to adapt to different external forces which are imposed on the cells. It is obvious that the relationship between the mechanism of cell adhering to the matrix and the morphology ＆distribution of actins needs more attention.

关 键 词：肌动蛋白 形态 分布 黏附性 切应力 癌细胞 

分 类 号：R341[医药卫生—基础医学]