甲磺酸加替沙星注射液治疗急性尿路感染的疗效评价  

Evaluation of the efficacy in treatment of acute urinary tract infection with gatifloxacin mesylate injection

作　　者：王汉民[1] 刘晓渭[1] 谭华[1] 许国双[1] 孙世仁[1] 

机构地区：[1]第四军医大学西京医院肾脏内科,陕西西安710033

出　　处：《第四军医大学学报》2007年第3期273-275,共3页Journal of the Fourth Military Medical University

摘　　要：目的:评价甲磺酸加替沙星注射液治疗急性尿路感染的安全性和有效性.方法:将48例急性尿路感染患者随机分为2组,分别接受试验药甲磺酸加替沙星注射液和对照药盐酸左氧氟沙星注射液治疗,观察其临床疗效和不良反应.结果:甲磺酸加替沙星注射液的临床有效率、细菌清除率、细菌敏感率和不良反应发生率分别为91%,90%,100%和20%,盐酸左氧氟沙星注射液分别为88%,86%,100%和24%.两组临床有效性和安全性无统计学显著性差异(P>0.05).结论:甲磺酸加替沙星注射液对急性尿路感染有较好的临床疗效,耐受性和安全性好,可作为一般敏感菌所致急性尿路感染的选择药物.AIM： To evaluate the efficacy and safety of gatifloxacin mesylate injection for acute urinary tract infection. METHODS： Forty-eight patients with acute urinary tract infection were randomly divided into 2 groups and given an injection of gatifloxacin mesylate and hydrochloric acid levofloxacin respectively. The efficacy and the adverse reaction were observed. RESULTS： The rate of clinical efficacy, the bacterial clearance rate, the bacterial sensitivity rate and the incidence of adverse reaction were 91%, 90%, 100% and 20% respectively in gatifloxacin mesylate injection group, and 88% , 86%, 100% and 24% respectively in hydrochloric acid levofloxacin injection group. There was no statistically significant differences in clinical efficacy and incidence of adverse reaction between the 2 groups （P 〉 0. 05 ）. CONCLUSION： Gatifloxacin mesylate injection has favorable clinical efficacy and tolerance and safety for acute urinary tract infection, and it can be used as an elective drug to treat acute urinary tract infection caused by common sensitive bacteria.

关 键 词：甲磺酸加替沙星 左氧氟沙星 泌尿道感染 

分 类 号：R978.1[医药卫生—药品] R969.4[医药卫生—药学]