严重烧伤早期大鼠肾脏内皮素受体mRNA变化的研究  

Changes of mRNA of endothelin receptor in kidneys of rats at the early stage after severe burns

作　　者：王旭[1] 吴雄飞[1] 高建川[1] 杨宗城[1] 黎鳌[1] 

机构地区：[1]第三军医大学附属西南医院烧伤研究所

出　　处：《第三军医大学学报》1996年第6期473-476,共4页Journal of Third Military Medical University

基　　金：国家自然科学基金

摘　　要：动态观察大鼠烧伤早期肾脏各时相点内皮素受体Ａ（ＥＴＡ）、内皮素受体Ｂ（ＥＴＢ）ｍＲＮＡ定量和分布的变化规律，发现肾脏ＥＴＡ、ＥＴＢｍＲＮＡ百分占有率在烧伤后１ｈ已明显升高，前者３ｈ达高峰，后者６ｈ达高峰，皮质以ＥＴＡ为主，髓质以ＥＴＢ为主。The changes of the quantity and distribution of mRNA of endothelin receptor A (ETA) and endothelin receptor B (ETB) in rat kidneys at different time phases during the early stage after severe burns were dynamically observed. It was found that the percentages of ETA and ETB mRNA in kidneys were significantly elevated at the 1st hour postburn (the former reached its climax on the 3rd while the latter did so on the 6th hour postburn) and ETA mainly expressed in cortex and ETB in medulla. Our findings suggest that the changes of ET receptors participate in damage of the renal function.

关 键 词：烧伤 肾脏 内皮素 MRNA 

分 类 号：R644.02[医药卫生—外科学]