川楝素对K^+、Ca^(2+)通道活动及细胞内Ca^(2+)浓度的调控  

Toosendanin Modifies K^+-and Ca^(2+)-Channel Activity and Intracellular Ca^(2+) Concentration

作　　者：施玉樑[1] 王文萍[1] 

机构地区：[1]中国科学院上海生命科学研究院,上海200031

出　　处：《生物化学与生物物理进展》2007年第2期132-137,共6页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(39470302;39070323;39860249);国家科学技术委员会攀登计划(P805);国家重点基础研究计划(G1999054000);上海市基础研究重点项目(O2JC14011)资助~~

摘　　要：川楝素是我国学者从驱蛔中药中分离、鉴定的一个三萜化合物,已证明具选择地影响神经递质释放,有效地对抗肉毒中毒,促进细胞分化、凋亡,抑制肿瘤增殖,抑制昆虫发育和取食,影响K+、Ca2+通道活动等多种生物效应.综述了证明川楝素抑制多种K+通道,选择地易化L型Ca2+通道和进而升高胞内Ca+浓度的研究资料,并对川楝素产生这些生物效应的机制进行了讨论.Usage of the fruit and bark of a Melia-family plant as a digestive tract-parasiticide and agricultural insecticide was recorded about two thousant years ago in ancient China. Toosendanin （TSN）, a triterpenoid, is an effectual ingredient extracted from the plant. Studies have demonstrated that TSN selectively affects neurotransmitter release, effectively antagonizes botulism, induces cell differentiation and apoptosis and inhibits proliferation of various human cancer cells, inhibits feeding and dovelopment in insects and modifies K^＋-and Ca^2＋-channel activity. The research data to demonstrate that TSN inhibits K^＋-channel and facilitates L-type Ca^2＋-channel are summarized, and the mechanism of action of TSN is discussed.

关 键 词：川楝素 K^+通道 L型Ca^2+通道 细胞内CA^2+浓度 

分 类 号：R285.1[医药卫生—中药学] R338[医药卫生—中医学]