肺癌患者血清CEA、NSE、CA125、VEGF检测的临床意义  

Clinical Significance of Determination of Changes of Serum CEA,NSE,CA125 and VEGF Levels in Patients with Lung Cancer

作　　者：韩传操[1] 季雪静[1] 

机构地区：[1]徐州医学院附属医院,221002

出　　处：《放射免疫学杂志》2007年第1期18-19,共2页Journal of Radioimmanology

摘　　要：目的:探讨了血清CEA、NSE、CA125、VEGF水平在肺癌患者中的变化。方法:分别应用放射免疫分析和ELISA法对33例肺癌患者进行了血清CEA、NSE、CA125和VEGF水平测定,并以30名正常健康人作比较。结果:肺癌患者血清CEA、NSE、CA125和VEGF水平非常显著地高于正常人组(P<0.01),且CEA、NSE、CA125和VEGF呈明显正相关(r=0.6105、0.6283、0.6318,P<0.01)。结论:检测肺癌患者血清CEA、NSE、CA125和VEGF水平的变化对了解病情、指导临床实践均具有重要的临床价值。Objective To investigate the clinical significance of changes of serum CEA, NSE, CA125 and VEGF levels in patients with lung cancer. Methods Serum CEA, NSE, CA125 （with RIA） and VEGF levels （with ELISA） were detected in 33 cases of lung cancer and 30 controls. Results The levels of serum CEA, NSE, CA125 and VEGF were significantly higher in the patients than those in controls （P 〈 0.01 ）, serum CEA, NSE, CA125 and VEGF levels were mutually positively correlated （r = 0. 6105, 0. 6283, 0. 6318, P 〈 0.01 ）. Conclusion Serum CEA, NSE, CA125 and VEGF levels were closely related to the diseases process of lung cancer and were of prognostic values.

关 键 词：肺癌 癌胚抗原 神经元特异性烯醇化酶 血管内皮生长因子 

分 类 号：R446.11[医药卫生—诊断学]