三磷酸腺苷脂质体的研究进展  

Recent development in ATP-loaded liposomes

作　　者：皮凤梅[1] 屠锡德[1] 周建平[1] 

机构地区：[1]中国药科大学药学院,南京210009

出　　处：《药学与临床研究》2007年第1期1-5,共5页Pharmaceutical and Clinical Research

摘　　要：本文综述了近年来三磷酸腺苷(ATP)脂质体的研究进展。脂质体作为新载体可以提高ATP在体内的稳定性,并且能靶向于缺血的心肌和缺血的大脑,用于器官移植中能提高冷冻贮存器官的能级状态,提高移植的成活率,故制备稳定的ATP脂质体具有重要的意义。本文还综述了ATP脂质体的制备方法,探讨如何进一步提高脂质体的包裹率和靶向性,以用于临床。This article reviews the recent development in ATP-loaded liposomes. As a new drug delivery vehicle, liposomes can improve in vivo the stability of ATP and accumulate in infracted cardiac muscle and ischemic cerebrum. Supply of liposomally-entrapped ATP during preservation of transplant organs will improve its energy state and metabolism. So to prepare stable ATP-loaded liposome is of great significance. In the second part, it reviews the preparation method of ATP-loaded liposomes and pursues the method of raise its encapsulation ratio and accumulation in targeted area, so as to use it clinically.

关 键 词：三磷酸腺苷(ATP) 脂质体 包裹率 心肌靶向 脑靶向 肝靶向 

分 类 号：R942[医药卫生—药剂学]