川陈皮素自微乳的制备及其大鼠在体肠吸收动力学  

Preparation of nobiletin-loaded self-microemulsifying system and its absorption kinetics in rat intestines

作　　者：姚静[1] 卢韵[1] 周建平[1] 平其能[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009

出　　处：《中国药科大学学报》2007年第1期35-38,共4页Journal of China Pharmaceutical University

摘　　要：目的:制备川陈皮素自微乳制剂,以期提高其口服生物利用度,并研究其在大鼠小肠各部位的吸收情况。方法:测定川陈皮素自微乳的粒径、Zeta电位等理化参数,初步考察其稳定性;运用大鼠在体肠回流模型,采用HPLC法测定回流液中药物的浓度,考察药物的吸收。结果:制得的川陈皮素自微乳平均粒径为(17.9±1.5)nm,Zeta电位为-4.9mV,稳定性好。川陈皮素微乳在空肠的吸收速率最快,吸收速率常数Ka为(0.5298±0.0507)h-1;川陈皮素胶束在空肠段的吸收显著低于微乳组(P<0.05)。结论:川陈皮素自微乳制剂稳定,微乳对川陈皮素在大鼠小肠的吸收有明显的促进作用。Aim：To improve the oral bioavailability of the nobiletin, the nobiletin-loaded self-microemulsifying system was prepared and the absorption of nobiletin-loaded microemulsion in rat intestine was investigated in comparison with that of nobiletin-loaded micelle. Methods： The size, Zeta potential and stability of nobiletin-loaded selfmicroemulsifying system were investigated. In situ recirculation model was used and the concentration of nobiletin in the perfusate were determined by HPLC. Results：The particle size of the resulting microemulsion was（ 17.9 ± 1.5）nm with Zeta potential of- 4.9 mV. The nobiletin-loaded self-mieroemulsifying system was stable in 6 months stored at ambient. Compared with other segments,the absorption rate constant（ Ka）of（0.529 8± 0.050 7）h and the absorption percentage of nobiletin-loaded microemulsion at the jejunum were the largest. The absorption of nobiletin-loaded micelle at the jejunum was significantly lower than that of nobiletin-loaded microemulsion. Conclusion：The nobiletinloaded self-microemulsifying system is stable and might significantly improve the absorption of nobiletin in the intestinal tract.

关 键 词：川陈皮素 自微乳 在体肠回流模型 肠吸收 

分 类 号：R285[医药卫生—中药学]