可溶性细胞凋亡蛋白Fas在自身免疫性甲状腺疾病患者循环血中的表达  

Expressions of the circulating soluble Fas levels in patients with autoimmune thyroid disease

作　　者：谢克俭[1] 张琦[2] 潘芙蓉 夏玉祥[1] 徐云弟[2] 

机构地区：[1]温州医学院检验医学院实验中心,浙江温州325035 [2]温州医学院核医学科,浙江温州325027 [3]温州市中西医结合医院内科,浙江温州325000

出　　处：《温州医学院学报》2007年第1期36-38,共3页Journal of Wenzhou Medical College

基　　金：浙江省教育厅科研基金资助项目(20041050);温州市"新世纪551人才工程"基金资助项目(2004-551-2)

摘　　要：目的:探讨Graves病(GD)和桥本甲状腺炎(HT)患者循环血可溶性细胞凋亡蛋白Fas(sFas)的变化特征及其临床意义。方法:采用酶联免疫吸附试验(ELISA)和放射免疫分析法(RIA)分别检测52例GD、30例HT患者血清sFas和甲状腺激素水平,并进行相关性分析,30例年龄与性别相匹配的健康者作为正常对照。结果:GD患者血清sFas水平为(2.48±1.05)ng/ml,显著高于对照组的(1.34±0.41)ng/ml(P<0.01),且与促甲状腺激素受体抗体(TRAb)呈正相关(r=0.595,P<0.01);HT患者血清sFas水平为(0.99±0.32)ng/ml,显著低于对照组(P<0.01),与甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)呈负相关(r=-0.375、0.393,P<0.05)。结论:自身免疫性甲状腺疾病(AITD)患者体内存在sFas异常表达,并在AITD的发病机制中发挥着重要作用。Objective：To investigate expressions of the circulating soluble Fas（sFas） levels in patients with Graves disease and Hashimoto thyroiditis. Methods：Using the method of enzyme-linked immunosorbent assay（ELISA） and radioimmunoassay, the serum levels of sFas and thyroid hormone from 52 ease of GD and 30 ease of HT were measured, 30 age- and sex-matched healthy subjects were used as controls, and the results were compared with that of the control group. Results：The serum sFas levels（2.48±1.05） ng/ml of GD patients were significantly higher than that of the control group （1.34±0.41 ng/ml）（P〈0.01）, and the concentration of sFas was positively correlated with the titers of anti-thyrotropin（TSH） receptor antibody（r=0595,P〈0.01）, The serum sFas levels（0.99±0.32ng/ml） of HT patients were significantly lower than that of the control group（P〈0.01）, and the concentration of sFas was negative correlated with the TGAb and TMAb（ r=-0.375, 0.393,P〈0.05）, Conclusion： Abnormal serum concentration of sFas can be observed in patients with autoimmune thyroid disease（AITD）, and the circulating sFas may play a pivotal role in the pathogenesis of AITD.

关 键 词：GRAVES病 桥本甲状腺炎 自身免疫性甲状腺疾病 可溶性细胞凋亡蛋白Fas 

分 类 号：R392.32[医药卫生—免疫学]