阿托伐他汀对冠心病患者肱动脉内皮依赖性舒张功能的影响  

Influence of atorvastatin on endothelium-dependent diastolic function of brachial artery in patients with coronary artery disease

作　　者：刘丽文[1] 钱蕴秋[1] 杨力军[2] 李兰荪[3] 沈敏[3] 张军[1] 周晓东[1] 

机构地区：[1]第四军医大学西京医院超声诊断科,陕西西安710032 [2]西京医院泌尿外科 [3]西京医院心内科

出　　处：《西北国防医学杂志》2007年第1期26-28,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：陕西省科技攻关基金资助项目(2006K13-G1);全军医药卫生科研基金课题资助项目(02M007)

摘　　要：目的:应用高频超声观察冠心病(CAD)患者,经阿托伐他汀治疗后对肱动脉内皮依赖性舒张功能(EDD)的改善作用。方法:经冠脉造影(CAG)确诊为CAD患者59例,利用高频超声血管技术检测阿托伐他汀对CAD患者治疗前后肱动脉EDD的疗效。结果:阿托伐他汀治疗2年后,EDD比治疗前有明显改善(P<0.05),与对照组相比无显著性差异(P>0.05)。常规治疗组治疗2年后,EDD无明显改善(P>0.05),与阿托伐他汀组治疗后及对照组相比差异有显著性(P<0.05)。结论:阿托伐他汀具有改善EDD的作用。Objective： To observe the effect of atorvastatin on endothelium - dependent dilation （EDD） of brachial artery in patients with coronary artery disease （CAD） by using high - frequency ultrasonic imaging. Methods： Fifty- nine patients with CAD diagnosed by coronary angiography and high- frequency ultrasound were studied. High -frequency ultrasonic imaging was used to detect the changes of EDD of brachial artery after administration with atorvastatin. Results： Two years after atorvastatin treatment, the EDD of brachial artery was improved, and there was no significant difference between atorvastatin treatment group and healthy control group （ P 〉 0.05 ）. In conventional therapy group, the EDD of brachial artery had no significant improvement and there was a significant difference compared with atorvastatin treatment group and healthy control group （P 〈 0. 05 ）. Conclusion： Atorvastatin may be effective to stabilize and improve the EDD of arteries.

关 键 词：冠心病 阿托伐他汀 内皮依赖型舒张功能 

分 类 号：R541.4[医药卫生—心血管疾病]