以牛黄为主药的中药方剂拮抗正己烷所致氧化损伤的初步研究  

ANTAGONISM OF CHINESE PRESCRIPTION WITH BEZOAR AS MONARCH ON MOUSE'S LIPID PEROXIDATION INDUCED BY N-HEXANE

作　　者：王天成[1] 贾光[2] 王振宇[3] 王翔[2] 沈惠麒[3] 邰昌松[4] 

机构地区：[1]北京大学第三医院,北京100083 [2]北京大学医学部公共卫生学院,北京100083 [3]北京大学医学部校医院,北京100083 [4]深圳市宝安区疾病预防控制中心,深圳518101

出　　处：《中国中医药科技》2007年第1期11-12,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：深圳市科技局基金No.200304262

摘　　要：目的:探讨以人工牛黄为主药的中药方剂对正己烷所致小鼠脂质过氧化的拮抗作用。方法:40只CD小鼠随机分为4组,每组10只,分别为正常对照组、药物对照组、模型组和中药干预组,分别观察小鼠血清、肝、脑组织总抗氧化能力(TAOC)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)的变化。结果:正己烷染毒小鼠血清、肝、脑组织中TAOC水平明显降低,MDA含量明显增多,GSH-Px活性降低;采用以牛黄为主药的中药方剂进行干预可以明显改善血清和组织中的TAOC和GSH-Px水平,降低MDA含量。结论:以人工牛黄为主药的中药方剂可对正己烷引起的氧化损伤和肝、脑毒性起到一定的保护效应。Objective:To observe the antagonism of Chinese prescription with the bezoar as monarch on n-hexane peroxidation injury in mouse.Meth- ods:CD mice ingested the Chinese prescription with bezoar as monarch for 3 days before to take the n-hexane,the changes of TAOC,MDA and GSH-PX in serum,liver and brain were determined.Resluts:The TAOC level and GSH-Px activity in serum,liver and brain of model group were declined and the MDA level were higher significantly than that in normal group,the TAOC level and GSH-Px activity increased and MDA level decreased in Chinese prescription group.Conclusion:N-hexane could induce oxygen free radical damage,Chinese prescription with bezoar as monarch might have some protective effect on the liver and brain toxicity in mouse.

关 键 词：脂质过氧化作用/中医药疗法 中药(复方)/治疗应用 牛黄/治疗应用 小鼠 

分 类 号：R285.5[医药卫生—中药学]