衍生化气相色谱-质谱法测定氢化法制备的对氨基酚及其杂质  

Determiarltion of p-Aminophenol Prepared by Hydrogenation Method and Impurities by Precolumn Derivatization Gas Chromatography-Mass Spectrometry

作　　者：顾惠芬[1] 周黎明[1] 郑明生[1] 

机构地区：[1]北京防化指挥工程学院分析测试中心,北京102205

出　　处：《分析化学》1996年第11期1284-1286,共3页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金

摘　　要：研究用衍生化气相色谱－质谱法测定硝基苯催化氢化法生产的对氨基酚及其中杂质苯胺、4，4‘－二氨基二苯醚等。探讨了对氨基酚的萃取条件及色谱行为，选择了最佳衍生化方法。分析了对氨基酚及其衍生物的质谱灵敏度和裂解规律。用本方法分析了工业产品和废水作品，结果令人满意。The hydrogenation of nitrobenzene with stpported platinum catalysts is a new method to Produce p-aminophenol. p-Aminophenol and impurities such as aniline and 4, 4,diaminodiphenyl ether were determined by gas chromatography -mass spectrometry' Paminophenol was silanized with bis (trimethylsilyl )-triflioroacctamide and acctylated with acetic anhydride at 60~70℃ for 30 min respectively. It is shown that the silanization is bet ter than acetylation : the former gives no side products and has high GC-MS sensitivity .Names. formulas mass data and retention indexes of compounds are presented. The massfragmentation is interpreted and discussed . This method has been used for the analysis of industrial products and waste water.

关 键 词：气相色谱-质谱法 衍生化 对氨基酚 4 4'-二氨基二苯醚 

分 类 号：O625.634[理学—有机化学]