血清瘦素水平与冠状动脉病变的关系  

Relationship Between Serum Leptin Concentration and Angiographic Characteristic of Coronary Atherosclerosis

作　　者：姜兰斌 韩维权 

机构地区：[1]湖北省武汉市第十一医院检验科,武汉430015 [2]武汉市第五医院检验科

出　　处：《微循环学杂志》2007年第1期36-37,共2页Chinese Journal of Microcirculation

摘　　要：目的:分析血清瘦素(Leptin)水平与冠状动脉病变的关系。方法:采用放射免疫法检测冠心病患者及与其年龄、性别及体重指数相匹配的健康体检者的血清Leptin水平。冠心病组中根据是否发生心肌梗死,同时采用改良Gensini评分系统对冠状动脉病变程度进行评分后,栓测各组血清Leptin水平的变化。结果:冠心病组血清Leptin水平显著高于对照组(P<0.01);随着冠状动脉病变程度的加重,冠心病患者血清Leptin水平逐渐升高;Gensini积分为11分的患者血清Leptin水平明显高于积分为5分的患者(P<0.05)。结论:冠心病患者的血清Leptin水平明显高于健康人,并且随着冠状动脉病变程度的增加而升高。Objective: To explore the relationship between serum leptin concentration and angiographic characteristic of coronary atherosclerosis.Method: 127 CHD (coronary heart disease) patients who underwent coronary angiography and 95 healthy control subjects were recruited in this study. The angiographic characteristic of coronary atherosclerosis was defined with the method of modified Gensini score. The serum leptin concentrations were measured by radioimmunoassay.Results: The serum leptin concentration in the CHD group was significantly higher than those in the control group(P<0.01).With the development of atherosclerosis, the leptin concentrations were increased. There was a significant difference between patients with Gensini score 11 and 5(11.7±0.89 vs 7.58±0.4 ng/ml,P<0.05).Conclusion: The leptin concentration of the CHD group was significantly higher than those of the control group, and were positively related with the severity of atherosclerosis.

关 键 词：冠状动脉病变程度 血清瘦素水平 LEPTIN水平 冠心病患者 肥胖基因编码 动脉粥样硬化 多肽类激素 糖脂代谢 

分 类 号：R541.4[医药卫生—心血管疾病]