碱退式辅酶B_(12)类似物的合成和光谱性质  

Synthesis and Spectroscopic Properties of Coenzyme B_(12) Base - off Form Analogues

作　　者：罗来斌[1] 燕红[1] 唐雯霞[1] 陈慧兰[2] 

机构地区：[1]南京大学化学系,南京210093 [2]南京大学配位化学国家重点实验室,南京210093

出　　处：《化学学报》1996年第10期1030-1036,共7页Acta Chimica Sinica

基　　金：国家自然科学基金;江苏省自然科学基金资助的课题

摘　　要：本工作用改进的方法合成了一类新的辅酶Ｂ１２碱退式类似物－含２＇－脱氧核苷啉醇酰胺。它们分别是２＇，５＇－二脱氧尿苷钴啉醇酰胺－二脱氧腺苷钴啉醇酰胺（２＇ｄＡｄｏＣｂｉ），２＇５＇－二脱氧胞苷钴啉醇酰胺（２＇ｄＣｙｔＣｂｉ）以及５＇－脱氧胞苷钴啉醇酰胺。研究了它们的ＵＶ－Ｖｉｓ和＾１ＨＮＭＲ光谱性质，并且和相应钴胺素的有关性质作了比较。A new kind of analogues of coenzyme B12 base - off form, which are cobinamides containing 2'-deoxynucleosides, were synthesized by an improved method. They are 2',5'-dideoxyuridinylcobinamide, 2', 5' - didepxyadenosylcobinamide, 2', 5' - dideoxycytidylcobin -amde, and 5' - deoxythymidylcobinamide. All the four analogues were investigated by UV- Vis and 2D 1H NMR spectroscopies. The spectroscopic properties with those of their corresponding cobalamins were compared.

关 键 词：辅酶B12 钴啉醇酰胺 脱氧核苷 碱退式 光谱性质 

分 类 号：O629.8[理学—有机化学]